[HTML][HTML] Exosomal glypican-1 is elevated in pancreatic cancer precursors and can signal genetic predisposition in the absence of endoscopic ultrasound …

P Moutinho-Ribeiro, IA Batista, ST Quintas… - World Journal of …, 2022 - ncbi.nlm.nih.gov
BACKGROUND Individuals within specific risk groups for pancreatic ductal adenocarcinoma
(PDAC)[mucinous cystic lesions (MCLs), hereditary risk (HR), and new-late onset diabetes …

Exosomal glypican-1 discriminates pancreatic ductal adenocarcinoma from chronic pancreatitis

P Moutinho-Ribeiro, B Adem, I Batista, M Silva… - Digestive and Liver …, 2022 - Elsevier
Background and aims Pancreatic ductal adenocarcinoma (PDAC) diagnosis can be difficult
in a chronic pancreatitis (CP) background, especially in its mass forming presentation. We …

Diagnostic and prognostic value of circulating exosomal glypican-1 in pancreatic cancer: a meta-analysis

Z Qiao, E Wang, B Bao, X Tan, H Chen… - Laboratory …, 2024 - academic.oup.com
Background Pancreatic cancer (PC) is usually detected in the advanced stages. Liquid
biopsy has become a revolutionary strategy for cancer diagnosis and prognosis prediction …

[HTML][HTML] Glypican-1 is enriched in circulating-exosomes in pancreatic cancer and correlates with tumor burden

AE Frampton, MM Prado, E López-Jiménez… - Oncotarget, 2018 - ncbi.nlm.nih.gov
Background Glypican-1 (GPC1) is expressed in pancreatic ductal adenocarcinoma (PDAC)
cells and adjacent stromal fibroblasts. Recently, GPC1 circulating exosomes (crExos) have …

Elevated glypican‐1 expression is associated with an unfavorable prognosis in pancreatic ductal adenocarcinoma

H Lu, F Niu, F Liu, J Gao, Y Sun, X Zhao - Cancer medicine, 2017 - Wiley Online Library
Pancreatic ductal adenocarcinoma (PDAC) is the most lethal cancer in humans, with a 5‐
year survival rate of< 5%. Recently, glypican‐1 (GPC1)‐expressing circulating exosomes …

[HTML][HTML] Serum exosomal and serum glypican-1 are associated with early recurrence of pancreatic ductal adenocarcinoma

J Zhao, M Guo, Y Song, S Liu, R Liao, Y Zhang… - Frontiers in …, 2022 - frontiersin.org
Background The diagnostic performance and prognostic value of serum exosomal glypican
1 (GPC-1) in pancreatic ductal adenocarcinoma (PDAC) remain controversial. In this study …

Exosomal glypican-1 for risk stratification of pancreatic cystic lesions: A case of pathological progression in the absence of any suspicious imaging finding

P Moutinho-Ribeiro, P Costa-Moreira, B Adem, I Batista… - Pancreatology, 2020 - Elsevier
The clinical management of patients with pancreatic cystic lesions is of utmost importance to
identify those at high risk for pathological progression. Current recommendations are guided …

[HTML][HTML] Glypican-1 and glycoprotein 2 bearing extracellular vesicles do not discern pancreatic cancer from benign pancreatic diseases

F Lucien, V Lac, DD Billadeau, A Borgida, S Gallinger… - Oncotarget, 2019 - ncbi.nlm.nih.gov
Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease that is clinically asymptomatic
in its early stages of development. Non-invasive testing for pancreatic cancer biomarkers …

Combined exosomal GPC1, CD82, and serum CA19-9 as multiplex targets: a specific, sensitive, and reproducible detection panel for the diagnosis of pancreatic …

D Xiao, Z Dong, L Zhen, G Xia, X Huang, T Wang… - Molecular cancer …, 2020 - AACR
Pancreatic cancer is a highly lethal malignancy with poor prognosis due to the lack of early
symptoms and resultant late diagnosis. Thus, it is extremely urgent to establish a simple and …

[HTML][HTML] Glypican-1 in exosomes as biomarker for early detection of pancreatic cancer

M Herreros-Villanueva, L Bujanda - Annals of translational …, 2016 - ncbi.nlm.nih.gov
Abstract On June 24, 2015 Nature published an article entitle “Glypican-1 identifies cancer
exosomes and detects early pancreatic cancer'', which demonstrates that exosomes …