A dynamic immune response shapes COVID-19 progression

EZ Ong, YFZ Chan, WY Leong, NMY Lee… - Cell host & …, 2020 - cell.com
The inflammatory response to SARS-coronavirus-2 (SARS-CoV-2) infection is thought to
underpin COVID-19 pathogenesis. We conducted daily transcriptomic profiling of three …

COVID-19: inflammatory profile

Y Wang, S Perlman - Annual review of medicine, 2022 - annualreviews.org
Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of
coronavirus disease 2019 (COVID-19), has resulted in a pandemic that has had widespread …

Dysregulated innate and adaptive immune responses discriminate disease severity in COVID-19

NAF Janssen, I Grondman… - The Journal of …, 2021 - academic.oup.com
The clinical spectrum of COVID-19 varies and the differences in host response
characterizing this variation have not been fully elucidated. COVID-19 disease severity …

Overly exuberant innate immune response to SARS-CoV-2 infection

Z Zhou, L Ren, LI Zhang, J Zhong, Y Xiao, Z Jia, L Guo… - 2020 - papers.ssrn.com
The outbreaks of 2019 novel coronavirus disease (COVID-19) caused by SARS-CoV-2
infection has posed a severe threat to global public health. It is unclear how the human …

Distinct inflammatory profiles distinguish COVID-19 from influenza with limited contributions from cytokine storm

PA Mudd, JC Crawford, JS Turner, A Souquette… - Science …, 2020 - science.org
We pursued a study of immune responses in coronavirus disease 2019 (COVID-19) and
influenza patients. Compared to patients with influenza, patients with COVID-19 exhibited …

Upregulated type I interferon responses in asymptomatic COVID-19 infection are associated with improved clinical outcome

KI Masood, M Yameen, J Ashraf, S Shahid… - Scientific reports, 2021 - nature.com
Understanding key host protective mechanisms against SARS-CoV-2 infection can help
improve treatment modalities for COVID-19. We used a blood transcriptome approach to …

Inflammation and antiviral immune response associated with severe progression of COVID-19

Q Zhang, Y Meng, K Wang, X Zhang, W Chen… - Frontiers in …, 2021 - frontiersin.org
Coronavirus disease-2019 (COVID-19) is a novel respiratory disease induced by severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It remains poorly understood how …

The noncoding and coding transcriptional landscape of the peripheral immune response in patients with COVID‐19

H Tang, Y Gao, Z Li, Y Miao, Z Huang… - Clinical and …, 2020 - Wiley Online Library
Background COVID‐19 is currently a global pandemic, but the response of human immune
system to severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection …

Viral invasion and type I interferon response characterize the immunophenotypes during COVID-19 infection

L Wei, S Ming, B Zou, Y Wu, Z Hong, Z Li, X Zheng… - 2020 - papers.ssrn.com
The new coronavirus COVID-19 has spread globally and caused a pneumonia outbreak.
Although the whole genome sequences of COVID-19 have been rapidly obtained …

The dysregulated innate immune response in severe COVID-19 pneumonia that could drive poorer outcome

M Blot, JB Bour, JP Quenot, A Bourredjem… - Journal of translational …, 2020 - Springer
Background Although immune modulation is a promising therapeutic avenue in coronavirus
disease 2019 (COVID-19), the most relevant targets remain to be found. COVID-19 has …