The role of galectins in differentiation of acute myeloid leukemia cells

J Smith - 2022 - search.proquest.com
Galectins are a family of β-galactoside binding proteins with roles in cellular differentiation,
apoptosis, and cancer progression. To better understand this important class of proteins, HL …

Galectins and Pathologies: Role of Galectin-3 in the Communication between Leukemia Cells and the Microenvironment

N Heisterkamp, F Fei, J Groffen - Galectins and Disease …, 2012 - ACS Publications
Our recent studies in a tissue co-culture model have shown that Galectin-3 is synthesized by
both protective stromal cells and by precursor B-lineage acute lymphoblastic leukemia cells …

Potential roles of galectins in myeloid differentiation into three different lineages

MJ Abedin, Y Kashio, M Seki… - Journal of Leucocyte …, 2003 - academic.oup.com
Little is known about the roles of galectins, a family of β-galactoside-binding lectins, in
myeloid cell differentiation. In the present experiments, we used HL-60 cells as a model of …

Biphasic effect of recombinant galectin‐1 on the growth and death of early hematopoietic cells

V Vas, R Fajka‐Boja, G Ion, V Dudics, É Monostori… - Stem Cells, 2005 - academic.oup.com
Galectin‐1 is a member of the family of β‐galactoside binding animal lectins, galectins. Its
presence in the bone marrow has been detected; however, its role in the regulation of …

Galectin‐3 expression in differentiating human myeloid cells

N Le Marer - Cell Biology International, 2000 - Wiley Online Library
Galectin‐3 is an endogenous mammalian carbohydrate‐binding protein with affinity for ABH
group carbohydrate epitopes and polylactosamine glycans present on cell surface and …

Insights into O-GlcNAc-mediated regulation of galectin expression and secretion in promyelocytic HL-60 cells

AJ McTague - 2021 - search.proquest.com
Galectins are a family of-galactoside-binding proteins involved in cell stress responses
and differentiation. Galectins are multifunctional proteins widely studied in many cell models …

Promoter methylation might shift the balance of Galectin-3 & 12 expression in de novo adult acute myeloid leukemia patients

M Assem, RE El-Araby, AA Al-Karmalawy… - Frontiers in …, 2023 - frontiersin.org
Acute myeloid leukemia (AML) was reported as the most common type of leukemia among
adults. Galectins constitute a family of galactose-binding proteins reported to play a critical …

[PDF][PDF] Galectins in acute myeloid leukemia: Gene expression profiling with clinical emphasis

MM Abdelfattah, MM Assem, AA El Leithy… - Age (years), 2021 - researchgate.net
Purpose: Galectins family are animal lectins with a broad range of cellular functions. Many
galectins are repeatedly reported in several physiological changes and diseases including …

Galectins as potential emerging key targets in different types of leukemia

Y Zheng, W Feng, YJ Wang, Y Sun, G Shi… - European Journal of …, 2019 - Elsevier
Galectins are carbohydrate-binding proteins and these have very high affinity for β-
galactoside containing glycoproteins and glycolipids. Amongst sixteen types of galectin, the …

Galectin-3 stimulates cell proliferation

H Inohara, S Akahani, A Raz - Experimental cell research, 1998 - Elsevier
Galectin-3, a β-galactoside-binding protein, has been shown to be involved in multiple
biological processes through interaction with its complementary glycoconjugates. Here we …