Structural analysis of SARS-CoV-2 ORF8 protein: pathogenic and therapeutic implications

A Valcarcel, A Bensussen, ER Álvarez-Buylla… - Frontiers in …, 2021 - frontiersin.org
Current therapeutic strategies and vaccines against SARS-CoV-2 are mainly focused on the
Spike protein despite there are other viral proteins with important roles in COVID-19 …

SARS-CoV-2 ORF3a Protein as a Therapeutic Target against COVID-19 and Long-Term Post-Infection Effects

J Zhang, K Hom, C Zhang, M Nasr, V Gerzanich… - Pathogens, 2024 - mdpi.com
The COVID-19 pandemic caused by SARS-CoV-2 has posed unparalleled challenges due
to its rapid transmission, ability to mutate, high mortality and morbidity, and enduring health …

In silico Analysis of SARS-CoV-2 ORF8-Binding Proteins Reveals the Involvement of ORF8 in Acquired-Immune and Innate-Immune Systems

H Takatsuka, M Fahmi, K Hamanishi… - Frontiers in …, 2022 - frontiersin.org
SARS-CoV-2 is the causative agent of a new type of coronavirus infection, COVID-19, which
has rapidly spread worldwide. The overall genome sequence homology between SARS …

SARS-CoV-2 ORF8 and SARS-CoV ORF8ab: genomic divergence and functional convergence

S Mohammad, A Bouchama, B Mohammad Alharbi… - Pathogens, 2020 - mdpi.com
The COVID-19 pandemic, in the first seven months, has led to more than 15 million
confirmed infected cases and 600,000 deaths. SARS-CoV-2, the causative agent for COVID …

Understanding the role of SARS-CoV-2 ORF3a in viral pathogenesis and COVID-19

J Zhang, A Ejikemeuwa, V Gerzanich, M Nasr… - Frontiers in …, 2022 - frontiersin.org
The ongoing SARS-CoV-2 pandemic has shocked the world due to its persistence, COVID-
19-related morbidity and mortality, and the high mutability of the virus. One of the major …

SARS-CoV-2 ORF8: One protein, seemingly one structure, and many functions

S Vinjamuri, L Li, M Bouvier - Frontiers in immunology, 2022 - frontiersin.org
SARS-CoV-2 is the virus responsible for the COVID-19 pandemic. The genome of SARS-
CoV-2 encodes nine accessory proteins that are involved in host-pathogen interaction …

SARS-CoV-2 ORF8 is a viral cytokine regulating immune responses

M Kohyama, T Suzuki, W Nakai, C Ono… - International …, 2023 - academic.oup.com
Many patients with severe COVID-19 suffer from pneumonia and the elucidation of the
mechanisms underlying the development of this severe condition is important. The in vivo …

[HTML][HTML] A unique view of SARS-CoV-2 through the lens of ORF8 protein

SS Hassan, AAA Aljabali, PK Panda, S Ghosh… - Computers in biology …, 2021 - Elsevier
Immune evasion is one of the unique characteristics of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) attributed to its ORF8 protein. This protein modulates the …

Notable sequence homology of the ORF10 protein introspects the architecture of SARS-CoV-2

SS Hassan, D Attrish, S Ghosh, PP Choudhury… - International Journal of …, 2021 - Elsevier
Abstract The current Coronavirus Disease 19 (COVID-19) pandemic, caused by Severe
Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) shows similar pathology to …

SARS-CoV-2 ORF8 forms intracellular aggregates and inhibits IFNγ-induced antiviral gene expression in human lung epithelial cells

H Geng, S Subramanian, L Wu, HF Bu… - Frontiers in …, 2021 - frontiersin.org
Infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes
COVID-19, a disease that involves significant lung tissue damage. How SARS-CoV-2 …