jun-B inhibits and c-fos stimulates the transforming and trans-activating activities of c-jun

J Schütte, J Viallet, M Nau, S Segal, J Fedorko, J Minna - Cell, 1989 - cell.com
We have cloned the human jun-6 gene and determined its sequence and transforming and
trans-activating activities. jun-6 is less potent than c-jun in transforming and immortalizing …

Suppression of oncogene-induced transformation by a deletion mutant of c-jun.

PH Brown, R Alani, LH Preis, E Szabo, MJ Birrer - Oncogene, 1993 - europepmc.org
Jun and Fos proteins are DNA-binding proteins that are involved in the control of gene
expression through transcriptional regulation. We have made a deletion mutant of the c-jun …

jun-D: a third member of the jun gene family.

K Ryder, A Lanahan… - Proceedings of the …, 1989 - National Acad Sciences
The protooncogene c-jun encodes a component of the transcription factor AP-1. Both murine
c-jun and a related gene (jun-B) are rapidly activated in BALB/c3T3 cells by serum growth …

Mechanism of action of a dominant-negative mutant of c-Jun.

PH Brown, TK Chen, MJ Birrer - Oncogene, 1994 - europepmc.org
The AP-1 transcriptional activating complex, made up of Jun and Fos protein, is involved in
controlling many cellular processes such as cell proliferation, differentiation and …

Deregulated expression of human c-jun transforms primary rat embryo cells in cooperation with an activated c-Ha-ras gene and transforms rat-1a cells as a single …

J Schütte, JD Minna, MJ Birrer - Proceedings of the …, 1989 - National Acad Sciences
While the ability of the retroviral oncogene V-jun to transform chicken cells led to its
discovery, the oncogenic potential of its cellular homologue, c-jun, which encodes a …

Overexpression of c-jun, junB, or junD affects cell growth differently.

M Castellazzi, G Spyrou, N La Vista… - Proceedings of the …, 1991 - National Acad Sciences
The coding sequences of murine c-jun, junB, or junD, which code for proteins with practically
identical dimerization and DNA binding properties, were introduced into a nondefective …

c-Jun dimerizes with itself and with c-Fos, forming complexes of different DNA binding affinities

TD Halazonetis, K Georgopoulos, ME Greenberg… - Cell, 1988 - cell.com
The c-jun and c-fos proto-oncogenes encode proteins that form a complex which regulates
transcription from promoters containing AP-1 activation elements. c&n has specific DNA …

[HTML][HTML] Different members of the jun proto-oncogene family exhibit distinct patterns of expression in response to type beta transforming growth factor.

L Li, JS Hu, EN Olson - Journal of Biological Chemistry, 1990 - Elsevier
Type beta transforming growth factor (TGF-beta) is a multifunctional regulator of cell growth
and differentiation. In the BC3H1 muscle cell line, TGF-beta blocks the onset of …

Both Jun and Fos contribute to transcription activation by the heterodimer.

SL Hirai, B Bourachot, M Yaniv - Oncogene, 1990 - europepmc.org
Comparison of the amino acid sequence of the three members of the mouse jun proto-
oncogene family, c-jun, jun B and jun D, reveals several homologous segments. The most C …

Biochemical analysis of transcriptional activation by Jun: differential activity of c-and v-Jun

D Bohmann, R Tjian - Cell, 1989 - cell.com
The human proto-oncogene product, cJun, is a member of the AP-1 family of transcription
factors, which mediate the regulation of gene expression in response to extracellular …