The fibroproliferative response in acute respiratory distress syndrome: mechanisms and clinical significance

EL Burnham, WJ Janssen, DWH Riches… - European respiratory …, 2014 - Eur Respiratory Soc
Acute respiratory distress syndrome (ARDS) continues to be a major healthcare problem,
affecting> 190 000 people in the USA annually, with a mortality of 27–45%, depending on …

The cytokines of pulmonary fibrosis: much learned, much more to learn

IG Luzina, NW Todd, S Sundararajan, SP Atamas - Cytokine, 2015 - Elsevier
Organ fibrosis, the result of exaggerated, persistent, and often irreversible accumulation of
extracellular matrix, complicates numerous diseases in all organs and tissues and has …

Role of interleukins in the pathogenesis of pulmonary fibrosis

YX She, QY Yu, XX Tang - Cell Death Discovery, 2021 - nature.com
Interleukins, a group of cytokines participating in inflammation and immune response, are
proved to be involved in the formation and development of pulmonary fibrosis. In this article …

Emerging role of immune cells as drivers of pulmonary fibrosis

SE Mutsaers, T Miles, CM Prêle, GF Hoyne - Pharmacology & Therapeutics, 2023 - Elsevier
The pathogenesis of pulmonary fibrosis, including idiopathic pulmonary fibrosis (IPF) and
other forms of interstitial lung disease, involves a complex interplay of various factors …

Genetic studies provide clues on the pathogenesis of idiopathic pulmonary fibrosis

JA Kropski, WE Lawson, LR Young… - Disease models & …, 2013 - journals.biologists.com
Idiopathic pulmonary fibrosis (IPF) is a progressive and often fatal lung disease for which
there is no known treatment. Although the traditional paradigm of IPF pathogenesis …

Current models of pulmonary fibrosis for future drug discovery efforts

T Yanagihara, SG Chong, M Vierhout… - Expert opinion on …, 2020 - Taylor & Francis
Introduction Pulmonary fibrosis includes several lung disorders characterized by
progressive fibrosis, of which idiopathic pulmonary fibrosis (IPF) is a particularly severe form …

Bidirectional role of IL-6 signal in pathogenesis of lung fibrosis

T Kobayashi, K Tanaka, T Fujita, H Umezawa… - Respiratory …, 2015 - Springer
Background Various signals are known to participate in the pathogenesis of lung fibrosis.
Our aim was to determine which signal is predominantly mobilized in the early inflammatory …

Matrix regulation of idiopathic pulmonary fibrosis: the role of enzymes

DL Clarke, AM Carruthers, T Mustelin… - Fibrogenesis & tissue …, 2013 - Springer
Repairing damaged tissues is an essential homeostatic mechanism that enables clearance
of dead or damaged cells after injury, and the maintenance of tissue integrity. However …

Cytokines and pulmonary fibrosis

K Zhang, SH Phan - Neurosignals, 2004 - karger.com
In the past several years, significant progress in many aspects of pulmonary fibrosis
research has been made. Among them, the finding that a variety of cytokines play important …

Lung fibrosis and fibrosis in the lungs: is it all about myofibroblasts?

E Ortiz-Zapater, J Signes-Costa, P Montero, I Roger - Biomedicines, 2022 - mdpi.com
In the lungs, fibrosis is a growing clinical problem that results in shortness of breath and can
end up in respiratory failure. Even though the main fibrotic disease affecting the lung is …