Biological embedding of early-life adversity and a scoping review of the evidence for intergenerational epigenetic transmission of stress and trauma in humans

A Zhou, J Ryan - Genes, 2023 - mdpi.com
Severe or chronic stress and trauma can have a detrimental impact on health. Evidence
suggests that early-life adversity can become biologically embedded and has the potential …

Early environments, stress, and the epigenetics of human health

CJ Mulligan - Annual Review of Anthropology, 2016 - annualreviews.org
The field of social and behavioral epigenetics examines the role of epigenetic modifications
to mediate the effect of psychosocial stressors on an individual's health and well-being …

Transgenerational epigenetic contributions to stress responses: fact or fiction?

EJ Nestler - PLoS biology, 2016 - journals.plos.org
There has been increasing interest in the possibility that behavioral experience—in
particular, exposure to stress—can be passed on to subsequent generations through …

Evidence from clinical and animal model studies of the long-term and transgenerational impact of stress on DNA methylation

J Blaze, TL Roth - Seminars in cell & developmental biology, 2015 - Elsevier
While it is well-known that stress during development and adulthood can confer long-term
neurobiological and behavioral consequences, investigators have only recently begun to …

Prenatal stress and epigenetics

L Cao-Lei, SR De Rooij, S King, SG Matthews… - Neuroscience & …, 2020 - Elsevier
In utero exposure to environmental stress in both animals and humans could result in long-
term epigenome alterations which further lead to consequences for adaptation and …

Preclinical and clinical evidence of DNA methylation changes in response to trauma and chronic stress

N Matosin, C Cruceanu, EB Binder - Chronic Stress, 2017 - journals.sagepub.com
Exposure to chronic stress, either repeated severe acute or moderate sustained stress, is
one of the strongest risk factors for the development of psychopathologies such as post …

Epigenetics of prenatal stress in humans: the current research landscape

L Dieckmann, D Czamara - Clinical Epigenetics, 2024 - Springer
Fetal exposure to prenatal stress can have significant consequences on short-and long-term
health. Epigenetic mechanisms, especially DNA methylation (DNAm), are a possible …

Intergenerational transmission of DNA methylation signatures associated with early life stress

L Stenz, DS Schechter, SR Serpa… - Current …, 2018 - ingentaconnect.com
Early life stress in humans (ie maltreatment, violence exposure, loss of a loved one) and in
rodents (ie disrupted attachment or nesting, electric shock, restraint, predator odor) occurs …

Translating basic research knowledge on the biological embedding of early-life stress into novel approaches for the developmental programming of lifelong health

CM Heim, S Entringer, C Buss - Psychoneuroendocrinology, 2019 - Elsevier
This review integrates scientific knowledge obtained over the past few decades on the
biological mechanisms that contribute to the profound association between exposure to …

Transgenerational epigenetics of traumatic stress

A Jawaid, M Roszkowski, IM Mansuy - Progress in molecular biology and …, 2018 - Elsevier
Traumatic stress is a type of environmental experience that can modify behavior, cognition
and physiological functions such as metabolism, in mammals. Many of the effects of …