Exploring enzyme inhibition profiles of novel halogenated chalcone derivatives on some metabolic enzymes: Synthesis, characterization and molecular modeling …
Enzyme inhibition is a very active area of research in drug design and development.
Chalcone derivatives have a broad enzyme inhibitory activity and function as potential …
Chalcone derivatives have a broad enzyme inhibitory activity and function as potential …
Synthesis of novel organohalogen chalcone derivatives and screening of their molecular docking study and some enzymes inhibition effects
S Burmaoglu, EA Kazancioglu, R Kaya… - Journal of Molecular …, 2020 - Elsevier
Chalcones and their derivatives are increasing attention due to numerous biochemical and
pharmacological applications. In this study, a series of novel organohalogen chalcone …
pharmacological applications. In this study, a series of novel organohalogen chalcone …
Synthesis, molecular docking and some metabolic enzyme inhibition properties of biphenyl-substituted chalcone derivatives
The new synthesized biphenyl-substituted chalcone derivatives were evaluated against the
human carbonic anhydrase isoenzymes I and II (hCA I and hCA II), acetylcholinesterase …
human carbonic anhydrase isoenzymes I and II (hCA I and hCA II), acetylcholinesterase …
Cholinesterases, carbonic anhydrase inhibitory properties and in silico studies of novel substituted benzylamines derived from dihydrochalcones
A series of novel urea, sulfamide and N, N-dipropargyl substituted benzylamines were
synthesized from dihydrochalcones. The synthesized compounds were evaluated for their …
synthesized from dihydrochalcones. The synthesized compounds were evaluated for their …
Synthesis, characterization, evaluation of metabolic enzyme inhibitors and in silico studies of thymol based 2-amino thiol and sulfonic acid compounds
Eight new aminothiols (4a-g and 5) and three new sulfonic acid derivatives (6a-c) were
synthesized, and their structures were characterized. Inhibitory effects of the obtained …
synthesized, and their structures were characterized. Inhibitory effects of the obtained …
Synthesis, biological evaluation and molecular modeling studies of modulated benzyloxychalcones as potential acetylcholinesterase inhibitors
Acetylcholinesterase inhibitors (AChEIs) have become a significant target in the search for
an efficient treatment of Alzheimer's disease. Chalcone-based compounds display a strong …
an efficient treatment of Alzheimer's disease. Chalcone-based compounds display a strong …
Chalcone scaffolds exhibiting acetylcholinesterase enzyme inhibition: Mechanistic and computational investigations
This study was aimed to perform the mechanistic investigations of chalcone scaffold as
inhibitors of acetylcholinesterase (AChE) enzyme using molecular docking and molecular …
inhibitors of acetylcholinesterase (AChE) enzyme using molecular docking and molecular …
Anti-cholinesterase activity of chalcone derivatives: synthesis, in vitro assay and molecular docking study
Background: Chalcones, originated from natural product, have been broadly studied their
biological activity against various proteins which at the molecular level, are responsible for …
biological activity against various proteins which at the molecular level, are responsible for …
In Silico Studies and DNA Cleavage, Antioxidant, Acetylcholinesterase, and Butyrylcholinesterase Activity Evaluation of Bis-Histamine Schiff Bases and Bis …
In this work, a series of seven bis-histamine Schiff bases (H1–H4) and bis-spinaceamine
substituted derivatives (SPH1, SPH2, and SPH4) were successfully re-synthesized to …
substituted derivatives (SPH1, SPH2, and SPH4) were successfully re-synthesized to …
Designing heterocyclic chalcones, benzoyl/sulfonyl hydrazones: An insight into their biological activities and molecular docking study
The aim of this study is to investigate the antioxidant, anticholinesterase and the
antiproliferative activities of some chalcones, benzoyl and sulfonyl hydrazones. The …
antiproliferative activities of some chalcones, benzoyl and sulfonyl hydrazones. The …