[PDF][PDF] Novel aggregative trans-eqtl association analysis of known genetic variants detect trait-specific target gene-sets
Large scale genetic association studies have identified many trait-associated variants and
understanding the role of these variants in downstream regulation of gene-expressions can …
understanding the role of these variants in downstream regulation of gene-expressions can …
Aggregative trans-eQTL analysis detects trait-specific target gene sets in whole blood
Large scale genetic association studies have identified many trait-associated variants and
understanding the role of these variants in the downstream regulation of gene-expressions …
understanding the role of these variants in the downstream regulation of gene-expressions …
Trans-eQTL mapping in gene sets identifies network effects of genetic variants
Nearly all trait-associated variants identified in genome-wide association studies (GWASs)
are noncoding. The cis regulatory effects of these variants have been extensively …
are noncoding. The cis regulatory effects of these variants have been extensively …
Integrative genomics: quantifying significance of phenotype-genotype relationships from multiple sources of high-throughput data
Given recent advances in the generation of high-throughput data such as whole-genome
genetic variation and transcriptome expression, it is critical to come up with novel methods to …
genetic variation and transcriptome expression, it is critical to come up with novel methods to …
Identification of putative effector genes across the GWAS Catalog using molecular quantitative trait loci from 68 tissues and cell types
C Guo, KB Sieber, J Esparza-Gordillo, MR Hurle… - BioRxiv, 2019 - biorxiv.org
Identifying the effector genes from genome-wide association studies (GWAS) is a crucial
step towards understanding the biological mechanisms underlying complex traits and …
step towards understanding the biological mechanisms underlying complex traits and …
Probabilistic integration of transcriptome-wide association studies and colocalization analysis identifies key molecular pathways of complex traits
Integrative genetic association methods have shown great promise in post-GWAS (genome-
wide association study) analyses, in which one of the most challenging tasks is identifying …
wide association study) analyses, in which one of the most challenging tasks is identifying …
Limited overlap of eQTLs and GWAS hits due to systematic differences in discovery
Most signals in genome-wide association studies (GWAS) of complex traits point to
noncoding genetic variants with putative gene regulatory effects. However, currently …
noncoding genetic variants with putative gene regulatory effects. However, currently …
Transcriptome-wide gene-gene interaction associations elucidate pathways and functional enrichment of complex traits
It remains unknown to what extent gene-gene interactions contribute to complex traits. Here,
we introduce a new approach using predicted gene expression to perform exhaustive …
we introduce a new approach using predicted gene expression to perform exhaustive …
IBAS: Interaction-bridged association studies discovering novel genes underlying complex traits
P Kossinna, S Kumarapeli, Q Zhang - bioRxiv, 2023 - biorxiv.org
The contribution of genetic variants to a complex phenotype may be mediated by various
forms of complicated interactions. Currently, the discovery of genetic variants underlying …
forms of complicated interactions. Currently, the discovery of genetic variants underlying …
Reverse regression increases power for detecting trans-eQTLs
Trans-acting expression quantitative trait loci (trans-eQTLs) are genetic variants affecting the
expression of distant genes. They account for≥ 70% expression heritability and could …
expression of distant genes. They account for≥ 70% expression heritability and could …