Cellular DNA is constantly challenged by damage-inducing factors derived from exogenous
or endogenous sources. Thus, to protect against DNA damage, cells have evolved complex …

Cells evolve to actively coordinate nutrient availability with cellular activity in order to
maintain metabolic homeostasis. In addition, active pathways to repair DNA damage are …

Aging is characterized by a cumulative loss of genome integrity, which involves chromatin
reorganization, transcriptional dysregulation and the accumulation of DNA damage. Sirtuins …

Histone deacetylases (HDAC) are an important member of a group of enzymes that modify
chromatin conformation. Homologues of the yeast gene SIR2 in mammalian cells code type …

More than a decade ago, sirtuins were discovered as a highly conserved family of NAD+-
dependent enzymes that extend lifespan in lower organisms. In mammals, sirtuins are key …

The sirtuin gene family comprises an evolutionarily ancient set of NAD+ dependent protein
deacetylase and mono-ADP ribosyltransferase enzymes. Found in all domains of life …

Sirtuins, a family of NAD+-dependent deacetylases, help organisms to respond to metabolic
and genotoxic stress through diverse pathways, including metabolic homeostasis, cell …

Sirtuins, a family of protein deacetylases, promote cellular homeostasis by mediating
communication between cells and environment. The enzymatic activity of the mammalian …

Sirtuins are a class of enzyme with NAD+-dependent protein lysine deacylase activities.
They were initially discovered to regulate transcription and life span via histone deacetylase …

Downstream signaling of physiological and pathological cell responses depends on post-
translational modification such as ubiquitination. The mechanisms regulating downstream …