Diarylpentanoids, the privileged scaffolds in antimalarial and anti‐infectives drug discovery: A review

AH Ramli, SM Mohd Faudzi - Archiv der Pharmazie, 2023 - Wiley Online Library
Asia is a hotspot for infectious diseases, including malaria, dengue fever, tuberculosis, and
the pandemic COVID‐19. Emerging infectious diseases have taken a heavy toll on public …

[PDF][PDF] Naturally occurring 1, 5-diarylpentanoids: a review

N Celebioglu, U Ozgen - Organic Communications, 2017 - acgpubs.org
Naturally Occurring 1,5-Diarylpentanoids: A Review Page 1 REVIEW ARTICLE The article was
published by ACG Publications www.acgpubs.org/OC/index.htm © October-December 2017 …

Diarylpentanoids with antitumor activity: A critical review of structure-activity relationship studies

J Moreira, L Saraiva, MM Pinto, H Cidade - European Journal of Medicinal …, 2020 - Elsevier
Diarypentanoids are commonly considered as monocarbonyl analogues of curcumin. Since
the discovery of this compound in 1962, twenty one diarylpentanoids have been isolated …

Curcumin inspired synthesis of unsymmetrical diarylpentanoids with highly potent anti-parasitic activities: in silico studies and DFT-based stereochemical calculation

ZU Din, A dos Santos, MA Trapp, D Lazarin-Bidóia… - …, 2016 - pubs.rsc.org
Unsymmetrical diarylpentanoid analogues of curcumin have been synthesized by Claisen–
Schmidt condensation of different aldehydes and ketones. Anisaldehyde treated with 2 …

Bioactive Diarylpentanoids: Insights into the Biological Effects beyond Antitumor Activity and Structure–Activity Relationships

J Moreira, L Saraiva, MM Pinto, H Cidade - Molecules, 2022 - mdpi.com
Diarylpentanoids, a class of natural products and their synthetic analogs which are
structurally related to chalcones, have gained increasing attention due to their wide array of …

Preliminary insight on diarylpentanoids as potential antimalarials: In silico, in vitro pLDH and in vivo zebrafish toxicity assessment

AH Ramli, P Swain, MSAM Fahmi, F Abas, SW Leong… - Heliyon, 2024 - cell.com
Malaria remains a major public health problem worldwide, including in Southeast Asia.
Chemotherapeutic agents such as chloroquine (CQ) are effective, but problems with drug …

New diarylpentanoids and chalcones as potential antimicrobial adjuvants

J Moreira, F Durães, J Freitas-Silva… - Bioorganic & Medicinal …, 2022 - Elsevier
Antimicrobial resistance arises due to several adaptation mechanisms, being the
overexpression of efflux pumps (EPs) one of the most worrisome. In bacteria, EPs can also …

Synthesis, antimalarial activity in vitro, and docking studies of novel neolignan derivatives

GAN Pereira, GC Souza, LS Santos… - Chemical biology & …, 2017 - Wiley Online Library
The absence of effective vaccines against malaria and the difficulties associated with
controlling mosquito vectors have left chemotherapy as the primary control measure against …

Molecular pathways modulated by curcumin analogue, diarylpentanoids in cancer

F Paulraj, F Abas, N H. Lajis, I Othman, R Naidu - Biomolecules, 2019 - mdpi.com
While curcumin has a range of therapeutic benefits, its potent anticancer activity remains an
attractive avenue for anticancer research owing to the multifactorial nature of cancer itself …

Chalcone and curcumin derivatives: a way ahead for malarial treatment

D Kumar, M Kumar, A Kumar… - Mini reviews in …, 2013 - ingentaconnect.com
Malaria has been a major cause of morbidity and mortality in developing countries,
particularly in Sub-Saharan Africa and South Asia. The global malaria situation is …