Natural products as lead compounds for treatment of neglected tropical diseases: dream or reality?

J Moraes, JH Ghilardi Lago - Future Medicinal Chemistry, 2022 - Taylor & Francis
Neglected tropical diseases (NTDs), as classified by the WHO, include up to 20 conditions;
namely, Buruli ulcer, Chagas disease, dengue, chikungunya, dracunculiasis (Guinea worm …

Evaluation of ethnopharmacologically selected Vitex negundo L. for In vitro antimalarial activity and secondary metabolite profiling

MK Dwivedi, R Shukla, NK Sharma, A Manhas… - Journal of …, 2021 - Elsevier
Ethanopharmacological relevance Limited drugs, rise in drug resistance against frontline
anti-malarial drugs, non-availability of efficacious vaccines and high cost of drug …

[HTML][HTML] Marine antimalarials

E Fattorusso, O Taglialatela-Scafati - Marine Drugs, 2009 - mdpi.com
Malaria is an infectious disease causing at least 1 million deaths per year, and,
unfortunately, the chemical entities available to treat malaria are still too limited. In this …

Synthetic medicinal chemistry of selected antimalarial natural products

V Kumar, A Mahajan, K Chibale - Bioorganic & medicinal chemistry, 2009 - Elsevier
Natural products remain a rich source of novel molecular scaffolds for novel antimalarial
agents in the fight against malaria. This has been well demonstrated in the case of quinine …

Recent advances in anti-HIV natural products

IP Singh, HS Bodiwala - Natural product reports, 2010 - pubs.rsc.org
Covering: 2004 to April 2010 This review covers the recent advances in anti-HIV natural
products of various origins and chemical classes. The literature of the last seven years has …

[HTML][HTML] Synthesis and sar study of diarylpentanoid analogues as new anti-inflammatory agents

SW Leong, SMM Faudzi, F Abas, MFFM Aluwi… - Molecules, 2014 - mdpi.com
A series of ninety-seven diarylpentanoid derivatives were synthesized and evaluated for
their anti-inflammatory activity through NO suppression assay using interferone gamma (IFN …

Straightforward conversion of decoquinate into inexpensive tractable new derivatives with significant antimalarial activities

RM Beteck, D Coertzen, FJ Smit, LM Birkholtz… - Bioorganic & Medicinal …, 2016 - Elsevier
As part of a programme aimed at identifying rational new triple drug combinations for
treatment of malaria, tuberculosis and toxoplasmosis, we have selected quinolones as one …

Triterpenes and triterpenoids clinically useful with multiple targets in Cancer, malaria and more treatment: focus on potential therapeutic value

N Sultana - International Journal of Biochemistry Research & …, 2017 - asian.go4sending.com
Triterpenoids are the most promising plant secondary metabolites. Several triterpenoids,
including ursolic acid, oleanolic acid, betulinic acid, celastrol, pristimerin, lupeol and avicins …

[PDF][PDF] Role of plant secondary metabolites as potential antimalarial drugs.

V Sharma, P Saini, I Sheikh, SK Upadhyay, U Sharma… - 2022 - academia.edu
Malaria is a global problem affecting a large population without any demarcation between
developed and developing world communities. The already approved compounds for the …

Curcumin against malaria: from traditional medicine to development of synthetic analogs; a bioorganic approach

C Dohutia, D Chetia… - Current Traditional …, 2016 - ingentaconnect.com
Curcumin is well known to possess diverse therapeutic properties, one of which is its
antimalarial activity. It has been reported to show synergistic activity in combination with …