Background Malaria remains the major health problem responsible for many mortality and
morbidity in developing countries. Because of the development of resistance by Plasmodium …

Pulegone ((R)-5-Methyl-2-(1-methylethylidine) cyclohexanone) is a pharmacologically
active, natural monoterpene ketone obtained from leaves and flowering tops of the mint …

Infections caused by protozoan parasites such as Chagas disease, human African
trypanosomiasis, leishmaniasis, or malaria are responsible for considerable morbidity and …

A series of seven new (1, 3, 6, 7, 10, 12, and 13) and six (2, 4, 5, 8, 9, and 11) known
diarylpentanoid analogs were synthesized and assessed for their nitric oxide (NO) and α …

The rapid emergence of drug resistance to the current antimalarial agents has led to the
urgent need for the discovery of new and effective compounds. In this work, a series of 5 …

A series of polyoxygenated cinnamoylcoumarins was synthesized as conformationally
constrained analogs of cytotoxic diarylpentanoids. The title compounds were tested against …

Abstract The Coordination, Rationalization, and Integration of antiMALarial drug Discovery &
Development Initiatives (CRIMALDDI) Consortium, funded by the EU Framework Seven …

Trypanosoma cruzi is the etiologic agent of Chagas disease, which affects over seven
million people, especially in developing countries. Undesirable side effects are frequently …

Numerous modifications of the well-known antimalarial drug primaquine, both at the
quinoline ring and at the primary amino group, have been reported, mostly to obtain …

Malaria is a parasitic disease endemic to tropical and subtropical regions responsible for
hundreds of millions of clinical cases and hundreds of thousands of deaths yearly. Its agent …