A review on reported phytochemicals as druggable leads with antimalarial potential

A Guchait, A Kumar, R Singh, G Joshi… - Medicinal Chemistry …, 2023 - Springer
The science and practice of drug discovery and development is primarily benefitted from the
natural sources. The chemistry of natural products has inspired medicinal chemists to …

Case study of small molecules as antimalarials: 2-amino-1-phenylethanol (APE) derivatives

MJ Chaparro, J Vidal, I Angulo-Barturen… - ACS Medicinal …, 2014 - ACS Publications
Antiparasitic oral drugs have been associated to lipophilic molecules due to their intrinsic
permeability. However, these kind of molecules are associated to numerous adverse effects …

Structural insights and pharmaceutical relevance of plumbagin in parasitic disorders: A comprehensive review

AP Singh, A Sharma - Recent Advances in Anti-Infective Drug …, 2022 - ingentaconnect.com
Recently, natural products have been became the center of attraction for the scientific
society and exploration of their biologically abilities is proceeding continuously. In search for …

Alkaloids as antimalarial compounds: a review of recent studies

NAUM Saufi, UUM Hatta, FNAA Rashid… - Mini-Reviews in …, 2023 - ingentaconnect.com
Malaria is a parasitic infection caused by Plasmodium parasites that are transmitted to
humans through the bite of infected Anopheles mosquitoes. Malaria continues to contribute …

Discovery of New Hits as Antitrypanosomal Agents by In Silico and In Vitro Assays Using Neolignan-Inspired Natural Products from Nectandra leucantha

SC Araujo, FS Sousa, TA Costa-Silva, AG Tempone… - Molecules, 2021 - mdpi.com
In the present study, the phytochemical study of the n-hexane extract from flowers of
Nectandra leucantha (Lauraceae) afforded six known neolignans (1–6) as well as one new …

Antimalarial Activities of Alkyl Cyclohexenone Derivatives Isolated from the Leaves of Poupartia borbonica

A Ledoux, A St-Gelais, E Cieckiewicz… - Journal of natural …, 2017 - ACS Publications
Bioactivity-guided fractionation of the ethyl acetate extract of the leaves of Poupartia
borbonica led to the isolation of three new alkyl cyclohexenone derivatives 1–3, and named …

Stereocontrolled total synthesis of nonenolide

PR Sudina, DR Motati, A Seema - Journal of natural products, 2018 - ACS Publications
Nonenolide (1) was first isolated from the entomopathogenic fungus Cordyceps militaries
BCC2816 and exhibited good antimalarial activity against Plasmodium falciparum K1 …

Antiviral Sesqui-, Di-and Sesterterpenes

T Rezanka, L Siristova, K Sigler - Anti-Infective Agents in …, 2009 - ingentaconnect.com
Terpenoids, biosynthetically related ubiquitous compounds found in virtually all living
organisms from marine invertebrates to blooming plants, are derived from the same …

[PDF][PDF] In vitro potentiation of antimalarial activities by daphnetin derivatives against Plasmodium falciparum

F Huang, LH Tang, LQ Yu, YC Ni… - Biomedical and …, 2006 - researchgate.net
Objective To screen the antimalarial compounds of daphnetin derivatives against
Plasmodium falciparum in vitro. Method Plasmodium faciparum (FCC1) was cultured in vitro …

Plant-derived antimalarial agents: new leads and efficient phytomedicines. Part II. Non-alkaloidal natural products

R Batista, A De Jesus Silva Júnior, AB De Oliveira - Molecules, 2009 - mdpi.com
Malaria is still the most destructive and dangerous parasitic infection in many tropical and
subtropical countries. The burden of this disease is getting worse, mainly due to the …