Cancer has been a paradigmatic example of a complex disease. It is the second leading
cause of death worldwide. Knowledge acquired on the mechanisms and potential causes …

The transformation of normal cells into cancer cells and maintenance of the malignant state
and phenotypes are associated with genetic and epigenetic deregulations, altered cellular …

Cancer is a highly complex disease that is often characterized by vast changes in the
genetic and epigenetic landscape. Those changes result in altered protein expression levels …

Cancer is a heterogeneous disease, originating in different tissues and involving a number
of distinct molecular pathways. With the growing availability of high-throughput biological …

Rapid advancements in high-throughput omics technologies and experimental protocols
have led to the generation of vast amounts of scale-specific biomolecular data on cancer …

Cancer is now appreciated as not only a highly heterogenous pathology with respect to cell
type and tissue origin but also as a disease involving dysregulation of multiple pathways …

It is becoming evident that holistic perspectives toward cancer are crucial in deciphering the
overwhelming complexity of tumors. Single-layer analysis of genome-wide data has greatly …

Cancer is a complex disease involving multiple mechanisms and critical players, at broad
genomic, transcriptional, translational and/or biochemical levels. One could envision …

Over the past decade, we have witnessed an increasing number of large-scale studies that
have provided multi-omics data by high-throughput sequencing approaches. This has …

In order to understand how a cancer cell is functionally different from a normal cell it is
necessary to assess the complex network of pathways involving gene regulation, signaling …