Epigenetic alterations in cytochrome P450 oxidoreductase (Por) in sperm of rats exposed to tetrahydrocannabinol (THC)

KS Acharya, R Schrott, C Grenier, Z Huang… - Scientific reports, 2020 - nature.com
As marijuana legalization is increasing, research regarding possible long-term risks for
users and their offspring is needed. Little data exists on effects of paternal …

Sperm DNA methylation altered by THC and nicotine: Vulnerability of neurodevelopmental genes with bivalent chromatin

R Schrott, M Rajavel, K Acharya, Z Huang, C Acharya… - Scientific reports, 2020 - nature.com
Men consume the most nicotine and cannabis products but impacts on sperm epigenetics
are poorly characterized. Evidence suggests that preconception exposure to these drugs …

Cannabinoid exposure and altered DNA methylation in rat and human sperm

SK Murphy, N Itchon-Ramos, Z Visco, Z Huang… - Epigenetics, 2018 - Taylor & Francis
Little is known about the reproductive effects of paternal cannabis exposure. We evaluated
associations between cannabis or tetrahydrocannabinol (THC) exposure and altered DNA …

Cannabis use and the sperm epigenome: a budding concern?

R Schrott, SK Murphy - Environmental Epigenetics, 2020 - academic.oup.com
Abstract The United States is swiftly moving toward increased legalization of medical and
recreational cannabis. Currently considered the most commonly used illicit psychoactive …

Cessation of chronic delta-9-tetrahydrocannabinol use partially reverses impacts on male fertility and the sperm epigenome in rhesus macaques

JC Hedges, CB Hanna, LE Shorey-Kendrick… - Fertility and sterility, 2023 - Elsevier
Objective To determine whether discontinuation of delta-9-tetrahydrocannabinol (THC) use
mitigates THC-associated changes in male reproductive health using a rhesus macaque …

Sperm DNA methylation alterations from cannabis extract exposure are evident in offspring

R Schrott, JL Modliszewski, AB Hawkey… - Epigenetics & …, 2022 - Springer
Background Cannabis legalization is expanding and men are the predominant users. We
have limited knowledge about how cannabis impacts sperm and whether the effects are …

Refraining from use diminishes cannabis-associated epigenetic changes in human sperm

R Schrott, SK Murphy, JL Modliszewski… - Environmental …, 2021 - academic.oup.com
Cannabis use alters sperm DNA methylation, but the potential reversibility of these changes
is unknown. Semen samples from cannabis users and non-user controls were collected at …

Paternal THC exposure in rats causes long-lasting neurobehavioral effects in the offspring

ED Levin, AB Hawkey, BJ Hall, M Cauley… - Neurotoxicology and …, 2019 - Elsevier
Developmental neurotoxicity of a wide variety of toxicants mediated via maternal exposure
during gestation is very well established. In contrast, the impacts of paternal toxicant …

Effect of chronic THC administration in the reproductive organs of male mice, spermatozoa and in vitro fertilization

AP López-Cardona, I Ibarra-Lecue… - Biochemical …, 2018 - Elsevier
The increased use of cannabis as a therapeutic drug in recent years has raised some
concerns due to its potential effects on reproductive health. With regards to the male, the …

Cannabis and paternal epigenetic inheritance

F Mazzeo, R Meccariello - … Journal of Environmental Research and Public …, 2023 - mdpi.com
Cannabis is the most widely used illicit drug in Western counties and its abuse is particularly
high in male adolescents and young adults. Its main psychotropic component, the …