GM-CSF-based treatments in COVID-19: reconciling opposing therapeutic approaches

FM Lang, KMC Lee, JR Teijaro, B Becher… - Nature Reviews …, 2020 - nature.com
Therapeutics against coronavirus disease 2019 (COVID-19) are urgently needed.
Granulocyte–macrophage colony-stimulating factor (GM-CSF), a myelopoietic growth factor …

Targeting GM-CSF in COVID-19 pneumonia: rationale and strategies

A Bonaventura, A Vecchié, TS Wang, E Lee… - Frontiers in …, 2020 - frontiersin.org
COVID-19 is a clinical syndrome ranging from mild symptoms to severe pneumonia that
often leads to respiratory failure, need for mechanical ventilation, and death. Most of the lung …

Therapeutic blockade of granulocyte macrophage colony-stimulating factor in COVID-19-associated hyperinflammation: challenges and opportunities

P Mehta, JC Porter, JJ Manson, JD Isaacs… - The Lancet …, 2020 - thelancet.com
The COVID-19 pandemic is a global public health crisis, with considerable mortality and
morbidity exerting pressure on health-care resources, including critical care. An excessive …

Loss of GM-CSF-dependent instruction of alveolar macrophages in COVID-19 provides a rationale for inhaled GM-CSF treatment

C Bosteels, KFA Van Damme, E De Leeuw… - Cell Reports …, 2022 - cell.com
GM-CSF promotes myelopoiesis and inflammation, and GM-CSF blockade is being
evaluated as a treatment for COVID-19-associated hyperinflammation. Alveolar GM-CSF is …

Mavrilimumab in patients with severe COVID-19 pneumonia and systemic hyperinflammation (MASH-COVID): an investigator initiated, multicentre, double-blind …

PC Cremer, A Abbate, K Hudock… - The Lancet …, 2021 - thelancet.com
Background In patients with COVID-19, granulocyte-macrophage colony stimulating factor
(GM-CSF) might be a mediator of the hyperactive inflammatory response associated with …

Inflammatory profiles across the spectrum of disease reveal a distinct role for GM-CSF in severe COVID-19

RS Thwaites, A Sanchez Sevilla Uruchurtu… - Science …, 2021 - science.org
While it is now widely accepted that host inflammatory responses contribute to lung injury,
the pathways that drive severity and distinguish coronavirus disease 2019 (COVID-19) from …

Cytokines and chemokines in SARS-CoV-2 infections—therapeutic strategies targeting cytokine storm

A Pum, M Ennemoser, T Adage, AJ Kungl - Biomolecules, 2021 - mdpi.com
The recently identified severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
virus, the cause of coronavirus disease (COVID-19) and the associated ongoing pandemic …

Emerging aspects of cytokine storm in COVID-19: The role of proinflammatory cytokines and therapeutic prospects

R Dharra, AK Sharma, S Datta - Cytokine, 2023 - Elsevier
COVID-19 has claimed millions of lives during the last 3 years since initial cases were
reported in Wuhan, China, in 2019. Patients with COVID-19 suffer from severe pneumonia …

Macrophage activation syndrome and COVID-19

R Otsuka, K Seino - Inflammation and regeneration, 2020 - Springer
An emerging, rapidly spreading coronavirus SARS-CoV-2 is causing a devastating
pandemic. As we have not developed curative medicine and effective vaccine, the end of …

Role of monocytes/macrophages in Covid-19 pathogenesis: implications for therapy

J Gómez-Rial, I Rivero-Calle, A Salas… - Infection and Drug …, 2020 - Taylor & Francis
cov-Abstract Emerging studies from SARS-CoV-2-infected patients indicate a preponderant
role of monocytes/macrophages in the pathogenesis of this viral infection, in a similar way to …