Age-related immune response heterogeneity to SARS-CoV-2 vaccine BNT162b2

DA Collier, IATM Ferreira, P Kotagiri, RP Datir, EY Lim… - Nature, 2021 - nature.com
Although two-dose mRNA vaccination provides excellent protection against SARS-CoV-2,
there is little information about vaccine efficacy against variants of concern (VOC) in …

mRNA vaccine-elicited antibodies to SARS-CoV-2 and circulating variants

Z Wang, F Schmidt, Y Weisblum, F Muecksch… - Nature, 2021 - nature.com
Here we report on the antibody and memory B cell responses of a cohort of 20 volunteers
who received the Moderna (mRNA-1273) or Pfizer–BioNTech (BNT162b2) vaccine against …

SARS-CoV-2 Omicron boosting induces de novo B cell response in humans

WB Alsoussi, SK Malladi, JQ Zhou, Z Liu, B Ying… - Nature, 2023 - nature.com
The primary two-dose SARS-CoV-2 mRNA vaccine series are strongly immunogenic in
humans, but the emergence of highly infectious variants necessitated additional doses and …

Induction of robust cellular and humoral immunity against SARS-CoV-2 after a third dose of BNT162b2 vaccine in previously unresponsive older adults

AJ Romero-Olmedo, AR Schulz, S Hochstätter… - Nature …, 2022 - nature.com
Here we compared SARS-CoV-2-specific antibody and T-cell responses between older
adults (> 80 years old, n= 51) and a younger control group (20–53 years old, n= 46) after …

Increased memory B cell potency and breadth after a SARS-CoV-2 mRNA boost

F Muecksch, Z Wang, A Cho, C Gaebler, T Ben Tanfous… - Nature, 2022 - nature.com
The Omicron variant of SARS-CoV-2 infected many vaccinated and convalescent
individuals,–. Despite the reduced protection from infection, individuals who received three …

Lower vaccine-acquired immunity in the elderly population following two-dose BNT162b2 vaccination is alleviated by a third vaccine dose

L Renia, YS Goh, A Rouers, N Le Bert, WN Chia… - Nature …, 2022 - nature.com
Understanding the impact of age on vaccinations is essential for the design and delivery of
vaccines against SARS-CoV-2. Here, we present findings from a comprehensive analysis of …

Hybrid immunity improves B cells and antibodies against SARS-CoV-2 variants

E Andreano, I Paciello, G Piccini, N Manganaro… - Nature, 2021 - nature.com
The emergence of SARS-CoV-2 variants is jeopardizing the effectiveness of current
vaccines and limiting the application of monoclonal antibody-based therapy for COVID-19 …

Antibody responses to the BNT162b2 mRNA vaccine in individuals previously infected with SARS-CoV-2

JE Ebinger, J Fert-Bober, I Printsev, M Wu, N Sun… - Nature medicine, 2021 - nature.com
In a cohort of BNT162b2 (Pfizer–BioNTech) mRNA vaccine recipients (n= 1,090), we
observed that spike-specific IgG antibody levels and ACE2 antibody binding inhibition …

Evidence for increased breakthrough rates of SARS-CoV-2 variants of concern in BNT162b2-mRNA-vaccinated individuals

T Kustin, N Harel, U Finkel, S Perchik, S Harari… - Nature medicine, 2021 - nature.com
The BNT162b2 mRNA vaccine is highly effective against SARS-CoV-2. However,
apprehension exists that variants of concern (VOCs) may evade vaccine protection, due to …

[HTML][HTML] Phase I/II study of COVID-19 RNA vaccine BNT162b1 in adults

MJ Mulligan, KE Lyke, N Kitchin, J Absalon, A Gurtman… - Nature, 2020 - nature.com
Abstract In March 2020, the World Health Organization (WHO) declared coronavirus disease
2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 …