The impact of pre-existing comorbidities and therapeutic interventions on COVID-19
LA Callender, M Curran, SM Bates… - Frontiers in …, 2020 - frontiersin.org
Evidence from the global outbreak of SARS-CoV-2 has clearly demonstrated that individuals
with pre-existing comorbidities are at a much greater risk of dying from COVID-19. This is of …
with pre-existing comorbidities are at a much greater risk of dying from COVID-19. This is of …
Epithelial response to IFN‐γ promotes SARS‐CoV‐2 infection
J Heuberger, J Trimpert, D Vladimirova… - EMBO molecular …, 2021 - embopress.org
Abstract SARS‐CoV‐2, the agent that causes COVID‐19, invades epithelial cells, including
those of the respiratory and gastrointestinal mucosa, using angiotensin‐converting enzyme …
those of the respiratory and gastrointestinal mucosa, using angiotensin‐converting enzyme …
S-217622, a SARS-CoV-2 main protease inhibitor, decreases viral load and ameliorates COVID-19 severity in hamsters
M Sasaki, K Tabata, M Kishimoto, Y Itakura… - Science translational …, 2022 - science.org
In parallel with vaccination, oral antiviral agents are highly anticipated to act as
countermeasures for the treatment of the coronavirus disease 2019 (COVID-19) pandemic …
countermeasures for the treatment of the coronavirus disease 2019 (COVID-19) pandemic …
Potential therapeutic targets and promising drugs for combating SARS‐CoV‐2
H Zhou, Y Fang, T Xu, WJ Ni, AZ Shen… - British Journal of …, 2020 - Wiley Online Library
As of April 9, 2020, a novel coronavirus (SARS‐CoV‐2) had caused 89,931 deaths and
1,503,900 confirmed cases worldwide, which indicates an increasingly severe and …
1,503,900 confirmed cases worldwide, which indicates an increasingly severe and …
Symptomatic protective action of glycyrrhizin (licorice) in COVID-19 infection?
H Murck - Frontiers in immunology, 2020 - frontiersin.org
The role of the ACE2 enzyme in the COVID-19 infection is 2-fold, with opposing implications
for the disease development. 1. The membrane bound angiotensin converting enzyme 2 …
for the disease development. 1. The membrane bound angiotensin converting enzyme 2 …
Mast cell and eosinophil activation are associated with COVID-19 and TLR-mediated viral inflammation: implications for an anti-Siglec-8 antibody
S Gebremeskel, J Schanin, KM Coyle… - Frontiers in …, 2021 - frontiersin.org
Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 infection represents a
global health crisis. Immune cell activation via pattern recognition receptors has been …
global health crisis. Immune cell activation via pattern recognition receptors has been …
Antidepressant and Antipsychotic Drugs Reduce Viral Infection by SARS-CoV-2 and Fluoxetine Shows Antiviral Activity Against the Novel Variants in vitro
Repurposing of currently available drugs is a valuable strategy to tackle the consequences
of COVID-19. Recently, several studies have investigated the effect of psychoactive drugs on …
of COVID-19. Recently, several studies have investigated the effect of psychoactive drugs on …
[HTML][HTML] Critical role of type III interferon in controlling SARS-CoV-2 infection in human intestinal epithelial cells
Severe acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2) is an
unprecedented worldwide health problem that requires concerted and global approaches to …
unprecedented worldwide health problem that requires concerted and global approaches to …
Calming the storm: natural immunosuppressants as adjuvants to target the cytokine storm in COVID-19
AE Peter, BV Sandeep, BG Rao… - Frontiers in …, 2021 - frontiersin.org
The COVID-19 pandemic has caused a global health crisis, with no specific antiviral to treat
the infection and the absence of a suitable vaccine to prevent it. While some individuals …
the infection and the absence of a suitable vaccine to prevent it. While some individuals …
Non-steroidal anti-inflammatory drug use and outcomes of COVID-19 in the ISARIC Clinical Characterisation Protocol UK cohort: a matched, prospective cohort study
Background Early in the pandemic it was suggested that pre-existing use of non-steroidal
anti-inflammatory drugs (NSAIDs) could lead to increased disease severity in patients with …
anti-inflammatory drugs (NSAIDs) could lead to increased disease severity in patients with …