The ORF8 protein of SARS-CoV-2 mediates immune evasion through potently downregulating MHC-I

Y Zhang, J Zhang, Y Chen, B Luo, Y Yuan, F Huang… - biorxiv, 2020 - biorxiv.org
SARS-CoV-2 infection have caused global pandemic and claimed over 5,000,000 tolls–.
Although the genetic sequences of their etiologic viruses are of high homology, the clinical …

SARS-CoV-2 ORF9c is a membrane-associated protein that suppresses antiviral responses in cells

A Dominguez Andres, Y Feng, AR Campos, J Yin… - BioRxiv, 2020 - biorxiv.org
Disrupted antiviral immune responses are associated with severe COVID-19, the disease
caused by SAR-CoV-2. Here, we show that the 73-amino-acid protein encoded by ORF9c of …

Cytokine storm in coronavirus disease 2019 and adult-onset Still's disease: similarities and differences

J Meng, Y Ma, J Jia, M Wang, J Teng, H Shi… - Frontiers in …, 2021 - frontiersin.org
The catastrophic outbreak of coronavirus disease 2019 (COVID-19) is currently a public
emergency. Adult-onset Still's disease (AOSD) is an autoinflammatory disease characterized …

SARS-CoV-2 nsp13, nsp14, nsp15 and orf6 function as potent interferon antagonists

CK Yuen, JY Lam, WM Wong, LF Mak… - Emerging microbes & …, 2020 - Taylor & Francis
ABSTRACT The Coronavirus disease 2019 (COVID-19), which is caused by the novel SARS-
CoV-2 virus, is now causing a tremendous global health concern. Since its first appearance …

Attenuating the effects of novel COVID-19 (SARS-CoV-2) infection-induced cytokine storm and the implications

AB Rowaiye, OA Okpalefe… - Journal of …, 2021 - Taylor & Francis
The COVID-19 pandemic constitutes an arduous global health challenge, and the
increasing number of fatalities calls for the speedy pursuit of a remedy. This review …

A potential role of interleukin 10 in COVID-19 pathogenesis

L Lu, H Zhang, DJ Dauphars, YW He - Trends in Immunology, 2021 - cell.com
A unique feature of the cytokine storm in coronavirus disease 2019 (COVID-19) is the
dramatic elevation of interleukin 10 (IL-10). This was thought to be a negative feedback …

[HTML][HTML] The role of SARS-CoV-2 accessory proteins in immune evasion

M Zandi, M Shafaati, D Kalantar-Neyestanaki… - Biomedicine & …, 2022 - Elsevier
Many questions on the SARS-CoV-2 pathogenesis remain to answer. The SARS-CoV-2
genome encodes some accessory proteins that are essential for infection. Notably …

Interleukin-8 as a biomarker for disease prognosis of coronavirus disease-2019 patients

L Li, J Li, M Gao, H Fan, Y Wang, X Xu, C Chen… - Frontiers in …, 2021 - frontiersin.org
The widespread prevalence of coronavirus disease-2019 (COVID-19) which is caused by
severe respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, has resulted in a severe …

ORF9c and ORF10 as accessory proteins of SARS-CoV-2 in immune evasion

M Zandi - Nature Reviews Immunology, 2022 - nature.com
In a recent Perspective article in Nature Reviews Immunology (Wong, LY. R. & Perlman, S.
Immune dysregulation and immunopathology induced by SARS-CoV-2 and related …

ORF3a protein of severe acute respiratory syndrome coronavirus 2 inhibits interferon-activated janus kinase/signal transducer and activator of transcription signaling …

R Wang, X Yang, M Chang, Z Xue, W Wang… - Frontiers in …, 2021 - frontiersin.org
Coronavirus disease 2019 (COVID-19) has caused a crisis to global public health since its
outbreak at the end of 2019. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV …