Malaria remains a major public health problem worldwide, including in Southeast Asia.
Chemotherapeutic agents such as chloroquine (CQ) are effective, but problems with drug …

The increased prevalence of malaria requires continuous efforts towards the discovery of
natural antimalarial agents targeting important biochemical pathways of the parasite. The …

To combat resistance against current antimalarials, modifying key pharmacophores and
exploring novel parasite-specific drug targets remained one of the key drug design …

Malaria management remains a challenge, due to the resistance of malaria parasites to
current antimalarial agents. This resistance consequently delays the global elimination of …

In a search for new antiplasmodial agents, a series of thirty five diversely substituted
chalcones derived from a quinoline-chalcone scaffold eg (E)-3-(2-chloroquinolin-3-yl)-1-(2 …

Unsymmetrical diarylpentanoid analogues of curcumin have been synthesized by Claisen–
Schmidt condensation of different aldehydes and ketones. Anisaldehyde treated with 2 …

Malaria is responsible for approximately 1 million deaths annually; thus, continued efforts to
discover new antimalarials are required. A HTS screen was established to identify novel …

Objective: To synthesize chalcone derivatives and investigate their antimalarial activity
toward chloroquine-sensitive Plasmodium falciparum 3D7 (Pf3D7) strain; to develop …

Background Even though malaria is a completely preventable and treatable disease, it
remains a threat to human life and a burden to the global economy due to the emergence of …

We have studied inhibition of Plasmodium falciparum lactate dehydrogenase (pfLDH) by
dihydroxynaphthoic acid (DHNA) analogues derivatives of hemigossypol-sesquiterpene …