The molecular heterogeneity of cancer makes it challenging to delineate the underlying
mechanisms and optimize therapeutic avenues. Large-scale cancer datasets across …

Genome-scale studies focusing on molecular profiling of cancers across tissue types have
revealed a plethora of aberrations across the genomic, transcriptomic, and epigenomic …

Precision medicine is an approach that takes into account the influence of individuals'
genes, environment, and lifestyle exposures to tailor interventions. Here, we describe the …

Biomarker discovery is at the heart of personalized treatment planning and cancer precision
therapeutics, encompassing disease classification and prognosis, prediction of treatment …

Despite a growing body of knowledge on the mechanisms underlying the onset and
progression of cancer, treatment success rates in oncology are at best modest. Current …

Cancer is a complex disease at many different levels. The molecular phenomenology of
cancer is also quite rich. The mutational and genomic origins of cancer and their …

Cancer is a heterogeneous and complex disease and one of the leading causes of death
worldwide. The high tumor heterogeneity between individuals affected by the same cancer …

The future of cancer treatment lies in personalized strategies designed to specifically target
tumorigenic cell populations present in an individual. Although recent advances in directed …

Cancer is a highly complex disease that is often characterized by vast changes in the
genetic and epigenetic landscape. Those changes result in altered protein expression levels …