Senescent cells accumulate with age in vertebrates and promote aging largely through their
senescence‐associated secretory phenotype (SASP). Many types of stress induce …

ERCC1 (excision repair cross complementing‐group 1) is a mammalian endonuclease that
incises the damaged strand of DNA during nucleotide excision repair and interstrand cross …

Accumulation of senescent cells over time contributes to aging and age-related diseases.
However, what drives senescence in vivo is not clear. Here we used a genetic approach to …

Given the duration of ageing in humans, cell culture studies are a promising approach to the
study of human ageing. It is reasonable to assume that human ageing has, at least partly, a …

Many cellular stresses activate senescence, a persistent hyporeplicative state characterized
in part by expression of the p16 INK4a cell-cycle inhibitor. Senescent cell production occurs …

Cellular senescence is the irreversible growth arrest of individual mitotic cells, which as a
consequence display a radically altered phenotype that is thought to impair tissue function …

Senescent cells with replicative arrest can be generated during genotoxic, oxidative, and
oncogenic stress. Long-term retention of senescent cells in the body, which is attributed to …

The role of senescent cells has been implicated in various tissue dysfunctions associated
with aging, obesity and other pathological conditions. Currently, most transgenic mouse …

Cellular senescence is a state of permanent growth arrest and is thought to play a pivotal
role in tumor suppression. Cellular senescence may play an important role in tumor …

The free radical theory of aging postulates that the production of mitochondrial reactive
oxygen species is the major determinant of aging and lifespan. Its role in aging of the …