Following a first episode of psychiatric symptoms, patients have a high risk of subsequent
episodes of similar or variable nature. These subsequent recurrences characterize …

Psychotic disorders are severe, debilitating, and even fatal. The development of targeted
and effective interventions for psychosis depends upon on clear understanding of the timing …

Over the past two decades, the early intervention approach to psychotic disorders has
consolidated into a distinctive model. Data have been emerging to inform the effectiveness …

One of the recent major changes in the paradigm of conceptualizing mental disorders has
been a shift from silos of risk factors for specific DSM/ICD disorders to a paradigm of multiple …

Background A recent review reported that the median proportion of patients recovering from
schizophrenia was 13.5% and that this did not change over time. Various factors including …

Moncrieff J, Leo J (2010). A systematic review of the effects of antipsychotic drugs on brain
volume. Psychological Medicine. Published online: 20 January 2010. doi: 10.1017 …

In Psychiatry, understanding disease progression and unpredictable treatment response are
still a significant clinical challenge, leading to fruitless therapeutic trials. There is an urgent …

Patients with psychosis display structural brain abnormalities in multiple brain regions. The
disorder is characterized by a putative prodromal period called ultra-high-risk (UHR) status …

Many people suffering from psychotic illnesses experience persisting impairment of
occupational and social function. Evidence assembled since the classical description of …

The development of cognitive remediation programs has been a key step toward the
creation of a treatment approach to address the cognitive-symptom domain in psychosis …