miR‐33 in cardiometabolic diseases: lessons learned from novel animal models and approaches
Abstract miRNAs have emerged as critical regulators of nearly all biologic processes and
important therapeutic targets for numerous diseases. However, despite the tremendous …
important therapeutic targets for numerous diseases. However, despite the tremendous …
Genetic ablation of miR-33 increases food intake, enhances adipose tissue expansion, and promotes obesity and insulin resistance
While therapeutic modulation of miRNAs provides a promising approach for numerous
diseases, the promiscuous nature of miRNAs raises concern over detrimental off-target …
diseases, the promiscuous nature of miRNAs raises concern over detrimental off-target …
miR-33: a metabolic conundrum
AM Näär - Trends in Endocrinology & Metabolism, 2018 - cell.com
The miR-33 microRNAs (miRNAs) are crucial regulators of cholesterol/lipids, and may
represent therapeutic targets for the treatment of atherosclerosis. A recent report by Price et …
represent therapeutic targets for the treatment of atherosclerosis. A recent report by Price et …
Key regulatory miRNAs in lipid homeostasis: Implications for cardiometabolic diseases and development of novel therapeutics
Dysregulation of lipid metabolism is associated with cardiovascular/metabolic diseases,
including atherosclerosis, liver diseases and type 2 diabetes mellitus (T2DM). Several …
including atherosclerosis, liver diseases and type 2 diabetes mellitus (T2DM). Several …
miR-21 mimic blocks obesity in mice: A novel therapeutic option
MicroRNAs (miRNAs) are promising drug targets for obesity and metabolic disorders.
Recently, miRNA mimics are providing a unique mechanism of action that guides the …
Recently, miRNA mimics are providing a unique mechanism of action that guides the …
Emerging roles of microRNA-22 in human disease and normal physiology
J Xiong - Current molecular medicine, 2012 - ingentaconnect.com
MicroRNAs (miRNAs) are an abundant class of small noncoding RNAs that have critical
regulatory functions in various biological processes. MicroRNA-22 (miR-22) is a highly …
regulatory functions in various biological processes. MicroRNA-22 (miR-22) is a highly …
A role of miR‐27 in the regulation of adipogenesis
Q Lin, Z Gao, RM Alarcon, J Ye, Z Yun - The FEBS journal, 2009 - Wiley Online Library
MicroRNAs (miRNAs) are involved in a plethora of important biological processes, from
embryonic development to homeostasis in adult tissues. Recently, miRNAs have emerged …
embryonic development to homeostasis in adult tissues. Recently, miRNAs have emerged …
MicroRNAs 33, 122, and 208: a potential novel targets in the treatment of obesity, diabetes, and heart-related diseases
Despite decades of research, obesity and diabetes remain major health problems in the
USA and worldwide. Among the many complications associated with diabetes is an …
USA and worldwide. Among the many complications associated with diabetes is an …
microRNA miR-27b impairs human adipocyte differentiation and targets PPARγ
M Karbiener, C Fischer, S Nowitsch… - Biochemical and …, 2009 - Elsevier
Obesity has emerged as a global health problem with more than 1.1 billion adults to be
classified as overweight or obese, and is associated with type 2 diabetes, cardiovascular …
classified as overweight or obese, and is associated with type 2 diabetes, cardiovascular …
MicroRNAs and lipid metabolism
MicroRNAs have emerged as critical regulators of cholesterol metabolism and promising
therapeutic targets for treating cardiometabolic disorders including atherosclerosis. Here, we …
therapeutic targets for treating cardiometabolic disorders including atherosclerosis. Here, we …