Molecular mechanisms of vasculopathy and coagulopathy in COVID-19

S Al-Gburi, S Beissert, C Günther - Biological Chemistry, 2021 - degruyter.com
COVID-19 primarily affects the respiratory system and may lead to severe systemic
complications, such as acute respiratory distress syndrome (ARDS), multiple organ failure …

COVID-19: the role of excessive cytokine release and potential ACE2 down-regulation in promoting hypercoagulable state associated with severe illness

F Du, B Liu, S Zhang - Journal of thrombosis and thrombolysis, 2021 - Springer
The novel coronavirus disease (COVID-19) has become a universally prevalent infectious
disease. The causative virus of COVID-19 is severe acute respiratory syndrome coronavirus …

Endothelial dysfunction in SARS-CoV-2 infection

F Nappi, SS Avtaar Singh - Biomedicines, 2022 - mdpi.com
One of the hallmarks of the SARS-CoV-2 infection has been the inflammatory process that
played a role in its pathogenesis, resulting in mortality within susceptible individuals. This …

COVID-19 is a systemic vascular hemopathy: insight for mechanistic and clinical aspects

DM Smadja, SJ Mentzer, M Fontenay, MA Laffan… - Angiogenesis, 2021 - Springer
Abstract Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) is presenting as a systemic disease associated with …

Blood clots in COVID-19 patients: Simplifying the curious mystery

S Biswas, V Thakur, P Kaur, A Khan, S Kulshrestha… - Medical …, 2021 - Elsevier
The universal phenomenon of blood clotting is well known to be protective in external
cellular/tissue injury. However, the emergence of unusual thrombotic presentations in …

SARS-CoV-2 cell entry receptor ACE2 mediated endothelial dysfunction leads to vascular thrombosis in COVID-19 patients

A Kumar, RK Narayan, C Kumari, MA Faiq… - Medical hypotheses, 2020 - Elsevier
Several studies have described unusually high incidence of vascular thrombosis in
coronavirus disease-2019 (COVID-19) patients. Pathogenesis of the vascular thrombosis in …

Endothelial dysfunction in COVID-19: potential mechanisms and possible therapeutic options

MC Pelle, I Zaffina, S Lucà, V Forte, V Trapanese… - Life, 2022 - mdpi.com
SARS-CoV-2, a novel coronavirus found in Wuhan (China) at the end of 2019, is the
etiological agent of the current pandemic that is a heterogeneous disease, named …

[HTML][HTML] Role of SARS-COV-2 and ACE2 in the pathophysiology of peripheral vascular diseases

H Tanzadehpanah, E Lotfian, A Avan, S Saki… - Biomedicine & …, 2023 - Elsevier
The occurrence of a novel coronavirus known as severe acute respiratory syndrome-
coronavirus-2 (SARS-CoV-2), created a serious challenge worldwide. SARS-CoV-2 has …

The emerging threat of (micro) thrombosis in COVID-19 and its therapeutic implications

JD McFadyen, H Stevens, K Peter - Circulation research, 2020 - Am Heart Assoc
The recent emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
and the ensuing global pandemic has presented a health emergency of unprecedented …

Novel mechanism of the COVID-19 associated coagulopathy (CAC) and vascular thromboembolism

M Singh, S Pushpakumar, Y Zheng, I Smolenkova… - npj Viruses, 2023 - nature.com
Previous studies from our laboratory revealed that SARS-CoV-2 spike protein (SP)
administration to a genetically engineered model expressing the human angiotensin …