Pharmacological blockage of ICAM-1 improves angiotensin II-induced cardiac remodeling by inhibiting adhesion of LFA-1+ monocytes

QY Lin, PP Lang, YL Zhang, XL Yang… - American Journal …, 2019 - journals.physiology.org
Intercellular adhesion molecule-1 (ICAM-1) is a member of an immunoglobulin-like
superfamily of adhesion molecules that mediate leukocyte adhesion to vascular …

Blockade of intercellular adhesion molecule-1 prevents angiotensin II-induced hypertension and vascular dysfunction

PP Lang, J Bai, YL Zhang, XL Yang, YL Xia… - Laboratory …, 2020 - nature.com
Monocyte and adhesion infiltration into the arterial subendothelium are initial steps in
hypertension development. The endothelial intercellular adhesion molecule-1 (ICAM-1) has …

Upregulated expression of rat heart intercellular adhesion molecule-1 in angiotensin II–but not phenylephrine-induced hypertension

A Kiarash, PJ Pagano, M Tayeh, NE Rhaleb… - …, 2001 - Am Heart Assoc
Intercellular adhesion molecule-1 (ICAM-1), part of an immunoglobulin-like superfamily of
adhesion molecules, is involved in several cardiovascular diseases. We investigated …

Roles of intercellular adhesion molecule-1 in hypertensive cardiac remodeling

F Kuwahara, H Kai, K Tokuda, H Niiyama, N Tahara… - …, 2003 - Am Heart Assoc
Recently, we have shown that in rats with a suprarenal abdominal aortic constriction (AC),
pressure overload induces early perivascular fibro-inflammatory changes (transforming …

Intercellular adhesion molecule‐1 in the heart

HWM Niessen, PAJ Krijnen, CA Visser… - Annals of the New …, 2002 - Wiley Online Library
Intercellular adhesion molecule‐1 (ICAM‐1) belongs to the superfamily of immunoglobulin‐
like adhesion molecules. Up‐regulation of ICAM‐1 occurs in many different …

Cardiac ICAM-1 mediates leukocyte-dependent decreased ventricular contractility in endotoxemic mice

EY Davani, JH Boyd, DR Dorscheid… - Cardiovascular …, 2006 - academic.oup.com
Objective: Binding of ICAM-1 expressed on cardiomyocytes decreases cardiomyocyte
contractility in vitro by altering the intracellular Ca2+ transient. We tested the hypothesis that …

Blocking VCAM-1 ameliorates hypertensive cardiac remodeling by impeding macrophage infiltration

ZY Qiu, WJ Yu, J Bai, QY Lin - Frontiers in Pharmacology, 2022 - frontiersin.org
Cardiac remodeling is an important mechanism of heart failure, which frequently results from
leukocyte infiltration. Vascular cellular adhesion molecule-1 (VCAM-1) plays a critical role in …

Intercellular adhesion molecule 1 regulates left ventricular leukocyte infiltration, cardiac remodeling, and function in pressure overload–induced heart failure

AM Salvador, T Nevers, F Velázquez… - Journal of the …, 2016 - Am Heart Assoc
Background Left ventricular dysfunction and heart failure are strongly associated in humans
with increased circulating levels of proinflammatory cytokines, T cells, and soluble …

Effects of cross-linking ICAM-1 on the surface of human vascular smooth muscle cells: induction of VCAM-1 but no proliferation

C Lawson, ME Ainsworth, AM McCormack… - Cardiovascular …, 2001 - academic.oup.com
Objective: Intercellular adhesion molecule (ICAM)-1 is an immunoglobulin-like cell adhesion
molecule expressed by several cell types, including proliferating vascular smooth muscle …

Essential role of ICAM-1 in mediating monocyte adhesion to aortic endothelial cells

CG Kevil, RP Patel, DC Bullard - American Journal of …, 2001 - journals.physiology.org
Monocyte-endothelial cell interactions have been implicated in the pathogenesis of a
number of vascular diseases that target arterial and aortic endothelium, including …