Background The dysregulation of histone deacetylase (HDAC) protein expression or its
enzyme activity is implicated in a variety of diseases. Cardiac HDAC6 and HDAC8 enzyme …

Non-specific histone deacetylase (HDAC) inhibition reduces high blood pressure in
essential hypertensive animal models. However, the exact HDAC isoforms that play a critical …

Objective Non-selective histone deacetylase (HDAC) inhibitors are known to improve
hypertension. Here, we investigated the therapeutic effect and regulatory mechanism of the …

Objective: Histone deacetylase (HDAC) inhibitors have been reported to improve essential
and secondary hypertension. However, the specific HDAC that might serve as a therapeutic …

Histone deacetylases (HDACs) are transcriptional corepressors. Our recent study
demonstrated that HDAC4 protein specifically increases in mesenteric artery from …

Histone deacetylases (HDACs) are transcriptional coregulators. Recently, we demonstrated
that HDAC4, one of class IIa family members, promotes reactive oxygen species–dependent …

Cystathionine γ-lyase (CSEγ) is a hydrogen sulfide (H 2 S)-producing enzyme. Endothelial
H 2 S production can mediate vasodilatory effects, contributing to the alleviation of …

Here, we report that LMK235, a class I and histone deacetylase (HDAC6)‐preferential
HDAC inhibitor, reduces hypertension via inhibition of vascular contraction and vessel …

Background: Inhibition of histone deacetylase (HDAC) was reported to suppress cardiac
hypertrophy and fibrosis in various hypertrophic animal models. However, the HDAC …

Reactive oxygen species and proinflammatory cytokines contribute to cardiovascular
diseases. Inhibition of downstream transcription factors and gene modifiers of these …