Impacts of ecology, parasite antigenic variation, and human genetics on RTS, S/AS01e malaria vaccine efficacy
Abstract Purpose of Review Global malaria elimination has little chance of success without
an effective vaccine. The first malaria vaccine, RTS, S/AS01e, demonstrated moderate …
an effective vaccine. The first malaria vaccine, RTS, S/AS01e, demonstrated moderate …
Malaria transmission intensity likely modifies RTS, S/AS01 efficacy due to a rebound effect in Ghana, Malawi, and Gabon
Abstract Background RTS, S/AS01 is the first malaria vaccine to be approved and
recommended for widespread implementation by the World Health Organization (WHO) …
recommended for widespread implementation by the World Health Organization (WHO) …
Genetic diversity and protective efficacy of the RTS, S/AS01 malaria vaccine
DE Neafsey, M Juraska, T Bedford… - … England Journal of …, 2015 - Mass Medical Soc
Background The RTS, S/AS01 vaccine targets the circumsporozoite protein of Plasmodium
falciparum and has partial protective efficacy against clinical and severe malaria disease in …
falciparum and has partial protective efficacy against clinical and severe malaria disease in …
Background malaria incidence and parasitemia during the three-dose RTS, S/AS01 vaccination series do not reduce magnitude of antibody response nor efficacy …
Abstract Background RTS, S/AS01 has been recommended by WHO for widespread
implementation in medium to high malaria transmission settings. Previous analyses have …
implementation in medium to high malaria transmission settings. Previous analyses have …
The public health impact of malaria vaccine RTS, S in malaria endemic Africa: country-specific predictions using 18 month follow-up Phase III data and simulation …
Abstract Background The RTS, S/AS01 malaria vaccine candidate recently completed
Phase III trials in 11 African sites. Recommendations for its deployment will partly depend on …
Phase III trials in 11 African sites. Recommendations for its deployment will partly depend on …
Heterogeneity in malaria exposure and vaccine response: implications for the interpretation of vaccine efficacy trials
Background Phase III trials of the malaria vaccine, RTS, S, are now underway across
multiple sites of varying transmission intensity in Africa. Heterogeneity in exposure, vaccine …
multiple sites of varying transmission intensity in Africa. Heterogeneity in exposure, vaccine …
Assessing the safety, impact and effectiveness of RTS,S/AS01E malaria vaccine following its introduction in three sub-Saharan African countries: methodological …
N Praet, KP Asante, MC Bozonnat, EJ Akité, PO Ansah… - Malaria Journal, 2022 - Springer
Background Following a 30-year development process, RTS, S/AS01E (GSK, Belgium) is
the first malaria vaccine to reach Phase IV assessments. The World Health Organization …
the first malaria vaccine to reach Phase IV assessments. The World Health Organization …
Genotypic analysis of RTS, S/AS01E malaria vaccine efficacy against parasite infection as a function of dosage regimen and baseline malaria infection status in …
M Juraska, AM Early, L Li, SF Schaffner… - The Lancet Infectious …, 2024 - thelancet.com
Background The first licensed malaria vaccine, RTS, S/AS01 E, confers moderate protection
against symptomatic disease. Because many malaria infections are asymptomatic, we …
against symptomatic disease. Because many malaria infections are asymptomatic, we …
Efficacy of RTS, S malaria vaccines: individual-participant pooled analysis of phase 2 data
Background The efficacy of RTS, S/AS01 as a vaccine for malaria is being tested in a phase
3 clinical trial. Early results show significant, albeit partial, protection against clinical malaria …
3 clinical trial. Early results show significant, albeit partial, protection against clinical malaria …
[HTML][HTML] Country specific predictions of the cost-effectiveness of malaria vaccine RTS, S/AS01 in endemic Africa
Abstract Background RTS, S/AS01 is a safe and moderately efficacious vaccine considered
for implementation in endemic Africa. Model predictions of impact and cost-effectiveness of …
for implementation in endemic Africa. Model predictions of impact and cost-effectiveness of …
相关搜索
- malaria vaccines efficacy of rts
- human genetics impacts of ecology
- genetic diversity malaria vaccine
- malaria exposure vaccine response
- malaria vaccines analysis of phase
- cost effectiveness malaria vaccine
- individual participant efficacy of rts
- malaria vaccines individual participant
- methodological approaches malaria vaccine
- genetic diversity protective efficacy
- protective efficacy malaria vaccine