Sirtuins, initially described as histone deacetylases and gene silencers in yeast, are now
known to have many more functions and to be much more abundant in living organisms. The …

Ever since the discovery of sirtuins a decade ago, interest in this family of NAD-dependent
deacetylases has exploded, generating multiple lines of evidence implicating sirtuins as …

Sirtuins have been the focus of intense scrutiny since the discovery of Sir2 as a yeast
longevity factor. Functioning as either deacetylases or ADP ribosylases, Sirtuins are …

Sirtuins post-translationally modulate the function of many cellular proteins that undergo
reversible acetylation–deacetylation cycles, affecting physiological responses that have …

Sirtuins have emerged as therapeutic targets to treat age-related diseases. There are seven
human Sirtuins (SIRT1–7) that display diversity in cellular localization and function. Growing …

Members of the sirtuin family of protein deacetylases support and promote longevity in
diverse organisms and can extend life span when upregulated. Sirtuin pathways also …

Sirtuins are NAD-dependent deacetylases that are highly conserved from bacteria to human
and SIR2 was originally shown to extend lifespan in budding yeast (Imai et al., 2000; …

The sirtuins are highly conserved NAD‐dependent deacetylases that were shown to
regulate lifespan in lower organisms and affect diseases of aging in mammals, such as …

The controversy around sirtuins and their functions in aging has drawn in the past few years
as much attention, if not more, from the scientific community and the public as they did when …

Sirtuins are NAD+-dependent histone deacetylases regulating important metabolic
pathways in prokaryotes and eukaryotes and are involved in many biological processes …