A gene activated by growth factors is related to the oncogene v-jun.

K Ryder, LF Lau, D Nathans - Proceedings of the National …, 1988 - National Acad Sciences
We have recently identified by cDNA cloning a set of genes that are rapidly activated in
cultured mouse cells by protein growth factors. Here we report that the nucleotide sequence …

Induction of protooncogene c-jun by serum growth factors.

K Ryder, D Nathans - … of the National Academy of Sciences, 1988 - National Acad Sciences
We have previously reported that one of the genes that is rapidly induced in mouse 3T3 cells
by serum growth factors (jun-B) encodes a protein related to the onco-protein v-jun. By using …

jun-D: a third member of the jun gene family.

K Ryder, A Lanahan… - Proceedings of the …, 1989 - National Acad Sciences
The protooncogene c-jun encodes a component of the transcription factor AP-1. Both murine
c-jun and a related gene (jun-B) are rapidly activated in BALB/c3T3 cells by serum growth …

Characterization of junD: a new member of the jun proto‐oncogene family.

SI Hirai, RP Ryseck, F Mechta, R Bravo… - The EMBO journal, 1989 - embopress.org
In an extensive screen of a cDNA library prepared from serum‐stimulated mouse NIH 3T3
cells, we identified three distinct jun‐related clones. Two of them were carrying c‐jun and …

[HTML][HTML] Different members of the jun proto-oncogene family exhibit distinct patterns of expression in response to type beta transforming growth factor.

L Li, JS Hu, EN Olson - Journal of Biological Chemistry, 1990 - Elsevier
Type beta transforming growth factor (TGF-beta) is a multifunctional regulator of cell growth
and differentiation. In the BC3H1 muscle cell line, TGF-beta blocks the onset of …

v-jun encodes a nuclear protein with enhancer binding properties of AP-1

TJ Bos, D Bohmann, H Tsuchie, R Tijan, PK Vogt - Cell, 1988 - Elsevier
The jun oncogene of ASV17 is expressed as a 65 kd protein (p65 gag-jun) that contains
partial gag sequences at its amino terminus fused to jun sequences that make up the …

Overexpression of c-jun, junB, or junD affects cell growth differently.

M Castellazzi, G Spyrou, N La Vista… - Proceedings of the …, 1991 - National Acad Sciences
The coding sequences of murine c-jun, junB, or junD, which code for proteins with practically
identical dimerization and DNA binding properties, were introduced into a nondefective …

Biochemical analysis of transcriptional activation by Jun: differential activity of c-and v-Jun

D Bohmann, R Tjian - Cell, 1989 - cell.com
The human proto-oncogene product, cJun, is a member of the AP-1 family of transcription
factors, which mediate the regulation of gene expression in response to extracellular …

Deregulated expression of human c-jun transforms primary rat embryo cells in cooperation with an activated c-Ha-ras gene and transforms rat-1a cells as a single …

J Schütte, JD Minna, MJ Birrer - Proceedings of the …, 1989 - National Acad Sciences
While the ability of the retroviral oncogene V-jun to transform chicken cells led to its
discovery, the oncogenic potential of its cellular homologue, c-jun, which encodes a …

Oncogene jun encodes a sequence-specific trans- activator similar to AP-1

P Angel, EA Allegretto, ST Okino, K Hattori, WJ Boyle… - Nature, 1988 - nature.com
Proto-oncogenes encode proteins with three main sites of action: the cell-surface
membrane, the cytoplasm and the nucleus1, 2. Although the exact biochemical function of …