Lung-infiltrating macrophages create a marked inflammatory milieu in a subset of patients
with COVID-19 by producing a cytokine storm, which correlates with increased lethality …

Type I and III interferons (IFN-I/λ) are important antiviral mediators against SARS-CoV-2
infection. Here, we demonstrate that plasmacytoid dendritic cells (pDC) are the predominant …

SARS-CoV-2 fine-tunes the interferon (IFN)-induced antiviral responses, which play a key
role in preventing coronavirus disease 2019 (COVID-19) progression. Indeed, critically ill …

The exact role of innate immune cells upon infection with severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) and their contribution to the formation of the corona virus …

Plasmacytoid dendritic cells (pDCs) are specialized cells of the immune system that are
thought to be the main cellular source of type I interferon alpha (IFNα) in response to viral …

Abstract Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV)-2 infection induces
an exacerbated inflammation driven by innate immunity components. Dendritic cells (DCs) …

Understanding the molecular pathways driving the acute antiviral and inflammatory
response to SARS‐CoV‐2 infection is critical for developing treatments for severe COVID …

Clinical manifestations of coronavirus disease 2019 (COVID-19) vary from asymptomatic
virus shedding, nonspecific pharyngitis, to pneumonia with silent hypoxia and respiratory …

Respiratory infections, like the current COVID‐19 pandemic, target epithelial cells in the
respiratory tract. Alveolar macrophages (AMs) are tissue‐resident macrophages located …

Pathogenic human coronavirus infections, such as severe acute respiratory syndrome CoV
(SARS-CoV) and Middle East respiratory syndrome CoV (MERS-CoV), cause high morbidity …