Protein kinases (PKs) are allosteric enzymes that play an essential role in signal
transduction by regulating a variety of key cellular processes. Most PKs suffer …

Previous studies of the protein kinase, ERK2, using NMR and hydrogen-exchange
measurements have shown changes in dynamics accompanying its activation by …

Conformational selection by small molecules expands inhibitory possibilities for protein
kinases. Nuclear magnetic resonance (NMR) measurements of the mitogen-activated …

The mitogen-activated protein (MAP) kinase ERK2 contains recruitment sites that engage
canonical and noncanonical motifs found in a variety of upstream kinases, regulating …

Kinase Activity: Probing conformational dynamics to understand kinase inhibition | eLife Skip to
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Activation of the extracellular signal-regulated kinase-2 (ERK2) by phosphorylation has
been shown to involve changes in protein dynamics, as determined by hydrogen-deuterium …

Protein motions underlie conformational and entropic contributions to enzyme catalysis;
however, relatively little is known about the ways in which this occurs. Studies of the mitogen …

The activation loop segment in protein kinases is a common site for regulatory
phosphorylation. In extracellular signal-regulated kinase 2 (ERK2), dual phosphorylation …

Protein kinases are crucial components of the cell-signalling machinery that orchestrate and
convey messages to their downstream targets. Most often, kinases are activated upon a …

Mitogen-activated protein kinase (MAPK) signaling pathways play an essential role in the
transduction of environmental stimuli to the nucleus, thereby regulating a variety of cellular …