Origin and evolution of the neuroendocrine control of reproduction in vertebrates, with special focus on genome and gene duplications

S Dufour, B Quérat, H Tostivint… - Physiological …, 2020 - journals.physiology.org
In humans, as in the other mammals, the neuroendocrine control of reproduction is ensured
by the brain-pituitary gonadotropic axis. Multiple internal and environmental cues are …

[HTML][HTML] Neuroendocrinology of reproduction: Is gonadotropin-releasing hormone (GnRH) dispensable?

KE Whitlock, J Postlethwait, J Ewer - Frontiers in neuroendocrinology, 2019 - Elsevier
Gonadotropin releasing hormone (GnRH) is a highly conserved neuroendocrine
decapeptide that is essential for the onset of puberty and the maintenance of the …

Kobayashi Award 2019: The neuroendocrine regulation of the mammalian reproduction

H Tsukamura - General and comparative endocrinology, 2022 - Elsevier
Mammalian reproductive function is a complex system of many players orchestrated by the
hypothalamus-pituitary–gonadal (HPG) axis. The hypothalamic gonadotropin-releasing …

Discovery and evolutionary history of gonadotrophin‐inhibitory hormone and kisspeptin: new key neuropeptides controlling reproduction

K Tsutsui, GE Bentley, LJ Kriegsfeld… - Journal of …, 2010 - Wiley Online Library
Gonadotrophin‐releasing hormone (GnRH) is the primary hypothalamic factor responsible
for the control of gonadotrophin secretion in vertebrates. However, within the last decade …

Molecular coevolution of neuropeptides gonadotropin-releasing hormone and kisspeptin with their cognate G protein-coupled receptors

DK Kim, EB Cho, MJ Moon, S Park, JI Hwang… - Frontiers in …, 2012 - frontiersin.org
The neuropeptides gonadotropin-releasing hormone (GnRH) and kisspeptin (KiSS), and
their receptors gonadotropin-releasing hormone receptor (GnRHR) and kisspeptin receptor …

Dissecting the roles of gonadotropin-inhibitory hormone in mammals: studies using pharmacological tools and genetically modified mouse models

S Leon, M Tena-Sempere - Frontiers in Endocrinology, 2016 - frontiersin.org
Reproduction is essential for perpetuation of the species and, hence, is controlled by a
sophisticated network of regulatory factors of central and peripheral origin that integrate at …

[HTML][HTML] Physiology of GNRH and gonadotropin secretion

P Marques, K Skorupskaite, KS Rozario… - Endotext …, 2022 - ncbi.nlm.nih.gov
Gonadotropin hormone-releasing hormone (GnRH) is the key regulator of the reproductive
axis. Its pulsatile secretion determines the pattern of secretion of the gonadotropins follicle …

Kisspeptins and reproduction: physiological roles and regulatory mechanisms

L Pinilla, E Aguilar, C Dieguez, RP Millar… - Physiological …, 2012 - journals.physiology.org
Procreation is essential for survival of species. Not surprisingly, complex neuronal networks
have evolved to mediate the diverse internal and external environmental inputs that regulate …

Cellular mechanisms and integrative timing of neuroendocrine control of GnRH secretion by kisspeptin

M Beltramo, H Dardente, X Cayla, A Caraty - Molecular and Cellular …, 2014 - Elsevier
The hypothalamus integrates endogenous and exogenous inputs to control the pituitary–
gonadal axis. The ultimate hypothalamic influence on reproductive activity is mediated …

Kisspeptin as a master player in the central control of reproduction in mammals: an overview of kisspeptin research in domestic animals

H Okamura, T Yamamura… - Animal Science …, 2013 - Wiley Online Library
The hypothalamo‐pituitary‐gonadal (HPG) axis is the regulatory system for reproduction in
mammals. Because secretion of gonadotropin‐releasing hormone (GnRH) into the portal …