Paths to successful translation of new therapies for severe traumatic brain injury in the golden age of traumatic brain injury research: a Pittsburgh vision

PM Kochanek, TC Jackson, RM Jha… - Journal of …, 2020 - liebertpub.com
New neuroprotective therapies for severe traumatic brain injury (TBI) have not translated
from pre-clinical to clinical success. Numerous explanations have been suggested in both …

Progress, failures and new approaches for TBI research

DK Menon, AIR Maas - Nature Reviews Neurology, 2015 - nature.com
The past year saw the 40th anniversary of the Glasgow Coma Scale, which continues to be
effective for monitoring patients with traumatic brain injury. Three new clinical trials were …

Multi-center pre-clinical consortia to enhance translation of therapies and biomarkers for traumatic brain injury: operation brain trauma therapy and beyond

PM Kochanek, CE Dixon, S Mondello… - Frontiers in …, 2018 - frontiersin.org
Current approaches have failed to yield success in the translation of neuroprotective
therapies from the pre-clinical to the clinical arena for traumatic brain injury (TBI). Numerous …

A novel multicenter preclinical drug screening and biomarker consortium for experimental traumatic brain injury: operation brain trauma therapy

PM Kochanek, H Bramlett, WD Dietrich… - Journal of Trauma …, 2011 - journals.lww.com
Traumatic brain injury (TBI) is a leading cause of morbidity and mortality in Operation Iraqi
Freedom largely due to the emergence of blast-injury from attacks with improvised explosive …

Neuroprotection for traumatic brain injury

DJ Loane, BA Stoica, AI Faden - Handbook of clinical neurology, 2015 - Elsevier
Traumatic brain injury (TBI) is a major cause of mortality and morbidity worldwide. Despite
extensive preclinical research supporting the effectiveness of neuroprotective therapies for …

Exploring new routes for neuroprotective drug development in traumatic brain injury

T Janowitz, DK Menon - Science translational medicine, 2010 - science.org
Worldwide, traumatic brain injury (TBI) is a major cause of mortality and morbidity with a
substantial predicted increase in incidence. Despite an obvious need, there are no …

[PDF][PDF] Operation brain trauma therapy: approach to modeling, therapy evaluation, drug selection, and biomarker assessments for a multicenter pre-clinical drug …

PM Kochanek, HM Bramlett, CE Dixon, DA Shear… - J …, 2016 - researchgate.net
The importance of traumatic brain injury (TBI) is now being recognized in both civilian and
military settings over the range of injury severity. Given the magnitude of the problem, new …

Why does brain trauma research fail?

JL Alves, J Rato, V Silva - World Neurosurgery, 2019 - Elsevier
Traumatic brain injury (TBI) represents a major health care problem and a significant social
and economic issue worldwide. Considering the generalized failure in introducing effective …

Neuroprotection trials in traumatic brain injury

S Chakraborty, B Skolnick, RK Narayan - Current neurology and …, 2016 - Springer
Traumatic brain injury (TBI) is a significant cause of mortality and morbidity worldwide.
Current treatment of acute TBI includes surgical intervention when needed, followed by …

Bench-to-bedside and bedside back to the bench; coordinating clinical and experimental traumatic brain injury studies

DV Agoston, M Risling, BM Bellander - Frontiers in neurology, 2012 - frontiersin.org
Traumatic brain injury (TBI) is one of the leading cause of death and long-term disability in
virtually every country. Advances in neurointensive care have resulted in steadily …