L Zhang, SM Huang, LJ Lesko - Clinical Pharmacology & …, 2011 - Wiley Online Library
Transporters are membrane‐bound proteins that control the access of endogenous and xenobiotics (drugs) to various sites in the human body. They influence drug …
The efficacy of drug therapy results from the complex interplay of multiple processes that govern drug disposition and response. Most studies to date have focused on the contribution …
Uptake and efflux transporters determine plasma and tissue concentrations of a broad variety of drugs. They are localized in organs such as small intestine, liver, and kidney …
L Zhang, JM Strong, W Qiu, LJ Lesko… - Molecular …, 2006 - ACS Publications
Recently, increased interest in drug transporters and research in this area has revealed that drug transporters play an important role in modulating drug absorption, distribution, and …
F Müller, MF Fromm - Pharmacogenomics, 2011 - Taylor & Francis
Drug–drug interactions are a serious clinical issue. An important mechanism underlying drug–drug interactions is induction or inhibition of drug transporters that mediate the cellular …
A Tsuji - Drug metabolism and pharmacokinetics, 2002 - jstage.jst.go.jp
Since 1994, researchers have isolated various genes encoding transporter proteins involved in drug uptake into and eŒux from tissues that play key roles in the absorption …
Drug transporters are critically important for the absorption, distribution, metabolism, and excretion (ADME) of many drugs and endogenous compounds. Therefore, disruption of …
A comprehensive guide to drug transporters that influence the absorption, distribution, and elimination of drugs in the body The development of powerful expression cloning and …
CJ Endres, P Hsiao, FS Chung, JD Unadkat - european journal of …, 2006 - Elsevier
Transport proteins play an important role in the adsorption, distribution and elimination of a wide variety of drugs. Therefore, it is not surprising that transporter-based drug interactions …