Viral capsid, antibody, and receptor interactions: experimental analysis of the antibody escape evolution of canine parvovirus

RA López-Astacio, OF Adu, DJ Goetschius… - Journal of …, 2023 - Am Soc Microbiol
Canine parvovirus (CPV) is a small nonenveloped single-stranded DNA virus that causes
serious diseases in dogs worldwide. The original strain of the virus (CPV-2) emerged in …

The role of evolutionary intermediates in the host adaptation of canine parvovirus

KM Stucker, I Pagan, JO Cifuente, JT Kaelber… - Journal of …, 2012 - Am Soc Microbiol
The adaptation of viruses to new hosts is a poorly understood process likely involving a
variety of viral structures and functions that allow efficient replication and spread. Canine …

Limited intrahost diversity and background evolution accompany 40 years of canine parvovirus host adaptation and spread

IEH Voorhees, H Lee, AB Allison… - Journal of …, 2019 - Am Soc Microbiol
Canine parvovirus (CPV) is a highly successful pathogen that has sustained pandemic
circulation in dogs for more than 40 years. Here, integrating full-genome and deep …

[HTML][HTML] Host range relationships and the evolution of canine parvovirus

CR Parrish - Veterinary microbiology, 1999 - Elsevier
Canine parvovirus (CPV) is an example of an unusual class of emerging virus–those that
gain an altered host range through genetic variation and subsequently become widespread …

Global displacement of canine parvovirus by a host-adapted variant: structural comparison between pandemic viruses with distinct host ranges

LJ Organtini, AB Allison, T Lukk, CR Parrish… - Journal of …, 2015 - Am Soc Microbiol
ABSTRACT Canine parvovirus type 2 (CPV-2) emerged in 1978 and spread worldwide
within 2 years. Subsequently, CPV-2 was completely replaced by the variant CPV-2a, which …

High-resolution asymmetric structure of a Fab–virus complex reveals overlap with the receptor binding site

DJ Goetschius, SR Hartmann… - Proceedings of the …, 2021 - National Acad Sciences
Canine parvovirus is an important pathogen causing severe diseases in dogs, including
acute hemorrhagic enteritis, myocarditis, and cerebellar disease. Overlap on the surface of …

Single mutations in the VP2 300 loop region of the three-fold spike of the carnivore parvovirus capsid can determine host range

AB Allison, LJ Organtini, S Zhang… - Journal of …, 2016 - Am Soc Microbiol
Sylvatic carnivores, such as raccoons, have recently been recognized as important hosts in
the evolution of canine parvovirus (CPV), a pandemic pathogen of domestic dogs. Although …

Host-Specific Parvovirus Evolution in Nature Is Recapitulated by In Vitro Adaptation to Different Carnivore Species

AB Allison, DJ Kohler, A Ortega, EA Hoover… - PLoS …, 2014 - journals.plos.org
Canine parvovirus (CPV) emerged as a new pandemic pathogen of dogs in the 1970s and
is closely related to feline panleukopenia virus (FPV), a parvovirus of cats and related …

Characterization and recombination mapping of an antigenic and host range mutation of canine parvovirus

CR Parrish, LE Carmichael - Virology, 1986 - Elsevier
A mutant of canine parvovirus (CPV) was derived after culture of a highly passaged isolate
of CPV in the NLFK feline cell line. The virus (CPV-102/10) differed from the parental strain …

The natural host range shift and subsequent evolution of canine parvovirus resulted from virus-specific binding to the canine transferrin receptor

K Hueffer, JSL Parker, WS Weichert, RE Geisel… - Journal of …, 2003 - Am Soc Microbiol
Canine parvovirus (CPV) is a host range variant of a feline virus that acquired the ability to
infect dogs through changes in its capsid protein. Canine and feline viruses both use the …