COVID-19–associated morbidity and mortality have been attributed to a pathologic host
response. Two divergent hypotheses have been proposed: hyperinflammatory cytokine …

The clinical spectrum of COVID-19 varies and the differences in host response
characterizing this variation have not been fully elucidated. COVID-19 disease severity …

BACKGROUND Elevated levels of inflammatory cytokines have been associated with poor
outcomes among COVID-19 patients. It is unknown, however, how these levels compare …

The inflammatory response to SARS-coronavirus-2 (SARS-CoV-2) infection is thought to
underpin COVID-19 pathogenesis. We conducted daily transcriptomic profiling of three …

BACKGROUND Coronavirus disease 19 (COVID-19) is an emerging infectious disease
caused by SARS-CoV-2. Antiviral immune response is crucial to achieve pathogen …

Understanding key host protective mechanisms against SARS-CoV-2 infection can help
improve treatment modalities for COVID-19. We used a blood transcriptome approach to …

Summary The coronavirus disease 2019 (COVID-19) pandemic poses a current world-wide
public health threat. However, little is known about its hallmarks compared to other infectious …

We pursued a study of immune responses in coronavirus disease 2019 (COVID-19) and
influenza patients. Compared to patients with influenza, patients with COVID-19 exhibited …

Covid-19 features a delayed onset of critical illness occurring approximately one week from
the beginning of symptoms, which corresponds to the bridging of innate and adaptive …

The pandemic coronavirus infectious disease (COVID-19), caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), is rapidly spreading across the globe. In …