Objectives Despite decades of research using animals to develop pharmaceutical
treatments for patients who have had a stroke, few therapeutic options exist. The vast …

The consolidation of scientific knowledge proceeds through the interpretation and then
distillation of data presented in research reports, first in review articles and then in textbooks …

Over the last decades, tremendous progress has been made in our understanding of the
vascular, cellular, and molecular mechanisms leading to brain tissue injury after ischemic …

An important factor for successful translational stroke research is study quality. Low-quality
studies are at risk of biased results and effect overestimation, as has been intensely …

Despite the impressive efficacies demonstrated in preclinical research, hundreds of
potentially neuroprotective drugs have failed to provide effective neuroprotection for …

Based on research, mainly in rodents, tremendous progress has been made in our basic
understanding of the pathophysiology of stroke. After many failures, however, few scientists …

Translation from basic science bench research in ischemic stroke to bedside treatment of
patients suffering ischemic stroke remains a difficult challenge. Despite literally hundreds of …

2342 Stroke September 2017 upper limb, lower limb, kinesthesia, language, and other
specific neurological functions will be necessary to understand how the brain and the patient …

Translational stroke research is a challenging task that needs long term team work of the
stroke research community. Highly reproducible stroke models with excellent outcome …

Bosetti et al NINDS Workshop Recommendations 2633 academia, industry, the Food and
Drug Administration, and other public and private funding agencies. In the context of this …