In an effort to develop potent anti-influenza drugs that inhibit the activity of influenza virus
RNA-dependent RNA polymerase (IAV RdRp), a database of nucleoside triphosphates …

To develop potent drugs that inhibit the activity of influenza virus RNA dependent RNA
polymerase (RdRp), a set of compounds favipiravir, T-705, T-1105 and T-1106, ribavirin …

As influenza viruses have developed resistance towards current drugs, new inhibitors that
prevent viral replication through different inhibitory mechanisms are useful. In this study, we …

Background: Influenza is a seasonal disease that affects millions of people every year and
has a significant economic impact. Vaccines are the best strategy to fight this viral pathology …

Influenza viruses are responsible for contagious respiratory illnesses in humans and cause
seasonal epidemics and occasional pandemics worldwide. Previously, we identified a …

Influenza A virus infections cause significant morbidity and mortality, and novel antivirals are
urgently needed. Influenza RNA-dependent RNA polymerase (RdRp) activity has been …

Potential resistance to current anti-influenza drugs, as well as challenges in developing
vaccines to combat emerging influenza strains, mean that new strategies to combat both …

The RNA-dependent RNA polymerase of influenza A virus comprises conserved and
independently-folded subdomains with defined functionalities. The N-terminal domain of the …

Inhibition of the endonuclease activity of influenza RNA-dependent RNA polymerase is
recognized as an attractive target for the development of new agents for the treatment of …

Novel antiviral drugs, which are less prone to resistance development, are desirable
alternatives to the currently approved drugs for the treatment of potentially serious influenza …