New interventions are needed to reduce morbidity and mortality associated with malaria, as
well as to accelerate elimination and eventual eradication. Interventions that can break the …

The induction of cellular immunity, in conjunction with antibodies, may be essential for
vaccines to protect against blood-stage infection with the human malaria parasite …

Early clinical investigations of candidate malaria vaccines and antimalarial medications
increasingly employ an established model of controlled human malaria infection (CHMI) …

A malaria vaccine that prevents infection will be an important new tool in continued efforts of
malaria elimination, and such vaccines are under intense development for the major human …

Introduction Transmission-blocking vaccines (TBV) prevent community spread of malaria by
targeting mosquito sexual stage parasites, a life-cycle bottleneck, and will be used in …

Background Immunity to mosquito salivary proteins could provide protection against multiple
mosquito-borne diseases and significantly impact public health. We evaluated the safety …

Reduction of transmission is critical for effective malaria control. Transmission blocking
vaccines, which are intended to prevent the parasites from infecting the mosquito vectors …

Malaria is one of the most frequently occurring infectious diseases worldwide, with almost 1
million deaths and an estimated 243 million clinical cases annually. Several candidate …

This study compared safety, tolerability, and immunogenicity of the Oka/Merck varicella
vaccine and VARILRIX™[Oka-RIT strain SmithKline Beecham Biologicals] in healthy …

Malaria is still a leading cause of morbidity and mortality in human populations. Problems,
including drug-resistant parasites and insecticide resistant mosquitoes, ensure the …