The current study was designed to explore how disruption of specific molecular circuits in
the cerebral cortex may cause sensorimotor cortico-striatal community structure deficits in …

Abstract erbb4 is a known susceptibility gene for schizophrenia. Chandelier cells (ChCs,
also known as axo-axonic cells) are a distinct GABAergic interneuron subtype that …

Abstract Background and Hypothesis Converging lines of evidence suggest that dysfunction
of cortical GABAergic inhibitory interneurons is a core feature of psychosis. This dysfunction …

Neuregulin (NRG) and its cognate neuronal receptor tyrosine kinase ErbB4 are genetically
associated with increased risk for schizophrenia and its endophenotyes. 1–4 Moreover …

NRG1-ErbB4 signaling controls inhibitory circuit development in the mammalian cortex
through ErbB4-dependent regulation of GABAergic interneuron connectivity. Common …

Converging lines of evidence suggest that dysfunction of cortical parvalbumin-expressing
(PV+) GABAergic interneurons is a core feature of psychosis. This dysfunction is thought to …

The cerebellum plays a crucial role in higher cortical functions through a cerebellar-cerebral
circuit. However, the specific mechanisms through which the cerebellum contributes to the …

Cognitive deficits are critical determinants of schizophrenia morbidity. In this review, we offer
a mechanistic perspective regarding schizophrenia-related changes observed in prefrontal …

Objective Dysfunction in cortico-striatal circuitry represents a core component of the
pathophysiology in schizophrenia (SZ) but its potential as a candidate endophenotype of the …

Neuregulin 1 and its receptor ErbB4 are confirmed risk genes for schizophrenia, but the
neuropathological alterations in NRG1-ErbB4 in schizophrenia are unclear. The present …