Cellular disruption of lipid and cholesterol metabolism results in pathological processes
linked to metabolic and cardiovascular diseases. Classically, at the transcription stages, the …

MicroRNAs (miRNAs) represent an elegant mechanism of posttranscriptional control of gene
expression that serves to fine-tune biological processes. These tiny noncoding RNAs (20 …

Alterations in lipoprotein metabolism enhance the risk of cardiometabolic disorders
including type-2 diabetes and atherosclerosis, the leading cause of death in Western …

MicroRNAs (miRNAs, miRs) represent a group of powerful and versatile posttranscriptional
regulators of gene expression being involved in the fine control of a plethora of physiological …

Aberrant cholesterol/lipid homeostasis is linked to a number of diseases prevalent in the
developed world, including metabolic syndrome, type II diabetes, and cardiovascular …

MicroRNAs (miRNAs) are small, non-coding RNAs that have the ability to post-
transcriptionally regulate gene expression. Hundreds of miRNAs have been identified in …

Disruption of cellular cholesterol balance results in pathologic processes including
atherosclerosis, metabolic syndrome, type II diabetes and Alzheimer's disease. Maintenance …

Cholesterol metabolism is tightly regulated at the cellular level. In addition to classic
transcriptional regulation of cholesterol metabolism (eg by SREBP and LXR), members of a …

MicroRNAs (miRNAs) have recently emerged as a novel class of epigenetic regulators of
gene expression. They are systemically involved in the control of lipid metabolism through a …

Although the roles of the sterol response element binding protein-1 (SREBP1) and SREBP2
transcription factors in regulating fatty acid and cholesterol synthesis and uptake have been …