Despite achieving remarkable success in understanding the cellular, molecular and
pathophysiological aspects of stroke, translation from preclinical research has always …

Importance Preclinical stroke research has had a remarkably low translational success rate,
and the clinical need for novel neuroprotective therapeutics has gone largely unmet …

Acute ischaemic stroke accounts for 6.5 million deaths per year, and by 2030 will result in
the annual loss of over 200 million disability-adjusted life years globally. There have been …

Neuroprotective therapies: Preclinical reproducibility is only part of the problem | Science
Translational Medicine news careers commentary Journals Science Science brought to you …

Background and Purpose—The concept of neuroprotection is based on sound scientific data
derived in preclinical studies. However, candidate neuroprotectants have never been …

Neuroprotection aims to prevent salvageable neurons from dying. Despite showing efficacy
in experimental stroke studies, the concept of neuroprotection has failed in clinical trials …

Background: Stroke is one of the major challenges to health and the reason for increasing
disability-adjusted life years. Despite tremendous progress in preclinical studies, none of the …

Based on research, mainly in rodents, tremendous progress has been made in our basic
understanding of the pathophysiology of stroke. After many failures, however, few scientists …

Stroke is the world's second leading cause of mortality, with a high incidence of severe
morbidity in surviving victims. There are currently relatively few treatment options available …

Over the past decades, great progress has been made in clinical as well as experimental
stroke research. Disappointingly, however, hundreds of clinical trials testing neuroprotective …