Defining variant-resistant epitopes targeted by SARS-CoV-2 antibodies: A global consortium study

KM Hastie, H Li, D Bedinger, SL Schendel… - Science, 2021 - science.org
… target spike, we may deduce optimal combinations of monoclonal antibodies (mAbs) to
prevent and treat infection by emerging variants and to minimize the risk of viral escape. We can …

[HTML][HTML] Fruitful neutralizing antibody pipeline brings hope to defeat SARS-Cov-2

A Renn, Y Fu, X Hu, MD Hall, A Simeonov - Trends in pharmacological …, 2020 - cell.com
… development of neutralizing antibodies against COVID-… antibody development pipeline to
combat the potential escape plans of SARS-CoV-2, including somatic mutations and antibody-…

Highly synergistic combinations of nanobodies that target SARS-CoV-2 and are resistant to escape

FD Mast, PC Fridy, NE Ketaren, J Wang, EY Jacobs… - Elife, 2021 - elifesciences.org
… binding SARS- CoV- 2 spike by combining in vivo antibody … spike nanobodies and their
combinations by complementary … This work thus provides significant impacts on SARS- CoV- 2 …

[PDF][PDF] Prevention and therapy of SARS-CoV-2 and the B. 1.351 variant in mice

DR Martinez, A Schäfer, SR Leist, D Li, K Gully… - Cell reports, 2021 - cell.com
… Combining RDV and antibodies … to treat SARS-CoV-2 infections and the continued clinical
development of the C144 and C135 antibody combination to treat patients infected with SARS-…

SARS-CoV-2 neutralizing antibodies for COVID-19 prevention and treatment

D Li, GD Sempowski, KO Saunders… - Annual review of …, 2022 - annualreviews.org
… ; Figure 2) in combination with etesevimab (also known as LY-CoV016 or LY3832479). In
a phase II clinical trial, this combination significantly decreased SARS-CoV-2 log viral load in …

[HTML][HTML] A combination adjuvant for the induction of potent antiviral immune responses for a recombinant SARS-CoV-2 protein vaccine

S Jangra, JJ Landers, R Rathnasinghe… - Frontiers in …, 2021 - frontiersin.org
… and quality of the antibody responses towards both a homologous SARS-CoV-2 virus and a
antibodies conferred robust protection against challenge with the heterologous SARS-CoV-…

[PDF][PDF] Affinity maturation of SARS-CoV-2 neutralizing antibodies confers potency, breadth, and resilience to viral escape mutations

F Muecksch, Y Weisblum, CO Barnes, F Schmidt… - Immunity, 2021 - cell.com
… However, by reducing the selecting concentration of C549 and sequential passaging with
antibody 4 times, we obtained rVSV/SARSCoV-2 populations in which Y449H, E484K, F486L, …

[PDF][PDF] Structurally resolved SARS-CoV-2 antibody shows high efficacy in severely infected hamsters and provides a potent cocktail pairing strategy

S Du, Y Cao, Q Zhu, P Yu, F Qi, G Wang, X Du, L Bao… - Cell, 2020 - cell.com
combination of different NAbs are evaluated. Besides the VH3-53/VH3-66 antibodies, further
… able to bind RBD together with two other antibodies: S309 and CR3022 (Figure S7). These …

B. 1.526 SARS-CoV-2 variants identified in New York City are neutralized by vaccine-elicited and therapeutic monoclonal antibodies

H Zhou, BM Dcosta, MI Samanovic, MJ Mulligan… - MBio, 2021 - Am Soc Microbiol
… elicited antibodies neutralized the B.1.526 variant. One of the Regeneron therapeutic …
antibodies was less effective against the B.1.526 (E484K) variant but the two-antibody combination

[HTML][HTML] Breadth and function of antibody response to acute SARS-CoV-2 infection in humans

KYA Huang, TK Tan, TH Chen, CG Huang… - Plos …, 2021 - journals.plos.org
… Potent neutralising antibodies to the RBD of SARS-CoV-2 … -RBD interaction by anti-RBD
antibodies in two assays (Fig 3, … monoclonal antibody combination against SARS coronavirus