[PDF][PDF] Induction of pro-inflammatory cytokines (IL-1 and IL-6) and lung inflammation by Coronavirus-19 (COVI-19 or SARS-CoV-2): anti-inflammatory strategies

P Conti, G Ronconi, AL Caraffa… - J Biol Regul Homeost …, 2020 - researchgate.net
… Pro-inflammatory cytokine levels are correlated with CoV-19 replication and disease. It is …
of coronavirus-19 (CoV-19 or SARSCoV-2) infection and lung inflammation mediated by IL-1. J …

SARS-CoV-2 infection: The role of cytokines in COVID-19 disease

VJ Costela-Ruiz, R Illescas-Montes… - Cytokine & growth factor …, 2020 - Elsevier
… The key point in SARS-CoV-2 infection could be the depletion of antiviral defenses related
to innate immune response as well as an elevated production of inflammatory cytokines [41]. …

SARS-CoV-2 causes a different cytokine response compared to other cytokine storm-causing respiratory viruses in severely ill patients

M Olbei, I Hautefort, D Modos, A Treveil… - Frontiers in …, 2021 - frontiersin.org
… Although for a subset of pro-inflammatory cytokines, SARS-CoV-2 does induce a similar
response to the compared viruses, the literature reports conflicting results for a few important …

TLR2 senses the SARS-CoV-2 envelope protein to produce inflammatory cytokines

M Zheng, R Karki, EP Williams, D Yang… - Nature …, 2021 - nature.com
… Given the critical role of TLR2 in SARS-CoV-2 infection-induced inflammatory cytokine … of
mice after infection with SARS-CoV-2. Due to the receptor specificity of SARS-CoV-2, we used …

SARS-CoV-2 pathogenesis

MM Lamers, BL Haagmans - Nature reviews microbiology, 2022 - nature.com
… We describe how SARS-CoV-2 may infect the lower respiratory … was also found within
inflammatory monocytes and macrophages, … of pro-inflammatory cytokines by triggering pyroptosis …

SARS-CoV-2 infection induces a pro-inflammatory cytokine response through cGAS-STING and NF-κB

CJ Neufeldt, B Cerikan, M Cortese, J Frankish… - Communications …, 2022 - nature.com
… and SARS-CoV-2 infected lung epithelial cells were enriched for pro-inflammatory cytokines
We also demonstrate that SARS-CoV-2 infection leads specifically to NF-κB, but not IRF3 …

Cytokine storm induced by SARS-CoV-2

P Song, W Li, J Xie, Y Hou, C You - Clinica chimica acta, 2020 - Elsevier
… NF-κB complex is activated to promote the transcription of inflammatory cytokines; (d) IL-1 and
… of inflammatory cytokines. PRR activates the transcription of multiple cytokines and delays …

Lianhuaqingwen exerts anti-viral and anti-inflammatory activity against novel coronavirus (SARS-CoV-2)

L Runfeng, H Yunlong, H Jicheng, P Weiqi… - Pharmacological …, 2020 - Elsevier
… Pro-inflammatory cytokine expression levels upon SARS-CoV-… -229E and SARS-COV-2
increased the cytokine release such as … The change of cytokine profiles suggested that LH might …

Innate immune and inflammatory responses to SARS-CoV-2: Implications for COVID-19

SA Lowery, A Sariol, S Perlman - Cell Host & Microbe, 2021 - cell.com
… to SARS-CoV-2 in … on SARS-CoV-2 pathology, innate immune antagonism, and treatments.
We show that both interferon expression and signaling, as well as pro-inflammatory cytokine

SARS-CoV-2 infection and obesity: Common inflammatory and metabolic aspects

K Michalakis, I Ilias - Diabetes & Metabolic Syndrome: Clinical Research & …, 2020 - Elsevier
… nucleus leads to a cascade of pro-inflammatory cytokines [12]. Among all interleukins, IL-6
was found to be associated with a highly pathogenic SARS-CoV-2 infection, due to enhanced …