A small molecule compound with an indole moiety inhibits the main protease of SARS-CoV-2 and blocks virus replication

S Hattori, N Higashi-Kuwata, H Hayashi, SR Allu… - Nature …, 2021 - nature.com
… In the present study, we synthesized a panel of compounds based on previously … SARS-CoV
and demonstrated that two small molecule compounds, GRL-1720 16 and compound 5h 20 …

Progress on SARS-CoV-2 3CLpro inhibitors: inspiration from SARS-CoV 3CLpro peptidomimetics and small-molecule anti-inflammatory compounds

J Zhu, H Zhang, Q Lin, J Lyu, L Lu, H Chen… - Drug design …, 2023 - Taylor & Francis
… Small-molecule compounds targeting 3CLpro with both antiviral and anti-inflammatory …
screening and molecular docking techniques for small-molecule compounds with SARS-CoV-2 …

Advances in the development of SARS-CoV-2 Mpro inhibitors

L Agost-Beltrán, S de la Hoz-Rodríguez, L Bou-Iserte… - Molecules, 2022 - mdpi.com
compound active against MERS-CoV and SARS-CoV. The P2-P3 amide bond in the new …
In summary, new molecules acting as inhibitors of the main protease (Mpro) of SARS-CoV-2 …

Molecular mechanism of interaction between SARS-CoV-2 and host cells and interventional therapy

Q Zhang, R Xiang, S Huo, Y Zhou, S Jiang… - Signal transduction and …, 2021 - nature.com
… We then review the ongoing experimental studies and clinical trials of antibodies, peptides,
or small-molecule compounds with anti-SARS-CoV-2 activity, and discuss how these …

Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing

L Riva, S Yuan, X Yin, L Martin-Sancho, N Matsunaga… - Nature, 2020 - nature.com
… -like disease coronavirus disease … molecules to identify candidate therapeutic drugs for
COVID-19. We report the identification of 100 molecules that inhibit viral replication of SARS-CoV-…

[PDF][PDF] Potential natural compounds for preventing SARS-CoV-2 (2019-nCoV) infection

H Chen, Q Du - 2020 - researchgate.net
… the potential active compounds for anti-SARSCoV, and at the same time, predict the binding
affinity of those compounds to bind ACE2. In this study, by using the molecular docking and …

[HTML][HTML] Analysis of therapeutic targets for SARS-CoV-2 and discovery of potential drugs by computational methods

C Wu, Y Liu, Y Yang, P Zhang, W Zhong… - … Pharmaceutica Sinica B, 2020 - Elsevier
… provide new lead compounds and targets for further in vitro and in vivo studies of SARS-CoV-2, …
The above results suggest that these small-molecule compounds might be the potential …

Exploration of natural compounds with anti-SARS-CoV-2 activity via inhibition of SARS-CoV-2 Mpro

S Bharadwaj, A Dubey, U Yadava… - Briefings in …, 2021 - academic.oup.com
… To further understand the inhibitory potential of selected natural compounds against
SARS-CoV-2 M pro , the molecular docking results were compared with the reference ligand N3 …

Marine natural compounds as potents inhibitors against the main protease of SARS-CoV-2—a molecular dynamic study

MT Khan, A Ali, Q Wang, M Irfan, A Khan… - Journal of …, 2021 - Taylor & Francis
… Keeping in view the importance of marine compounds in antiviral activity, we investigated the
… , marine natural compounds may be used as a potential inhibitor against SARS-CoV-2 for …

Identification of new anti-nCoV drug chemical compounds from Indian spices exploiting SARS-CoV-2 main protease as target

Umesh, D Kundu, C Selvaraj, SK Singh… - Journal of …, 2021 - Taylor & Francis
molecules can be used as potential inhibitors against SARS-… chemical compounds from
Indian spices and compound structure … Structure of protein SARS-CoV-2 Mpro was downloaded …