… (16,17) provide further evidence for a synaptic component to … genomic insights into
schizophrenia susceptibility in the context of gene expression and synaptic function in the …

… Quality control was performed on the cohorts separately according to standards developed
by the Psychiatric Genomics Consortium (PGC) 3 including SNP missingness < 0.05 (before …

… -stage genome-wide association study of up to 76,755 individuals with schizophrenia and
243,649 control individuals, we report common variant associations at 287 distinct genomic …

… These features raise several challenges for the development of rationally designed treatments.
First, since it is not currently possible to reliably predict who will develop schizophrenia, …

… normal synaptic development and evidence from structural and functional imaging and
post-mortem studies that this is abnormal in people at risk and with schizophrenia. … Genome-wide …

… analyses found that genes within reported schizophrenia genome-wide association study
(… , including synaptic functions implicated in brain development. Rare variant discovery in …

… Using a functional genomics approach, we integrated transcriptomic data from the developing
human brain, genome-wide association findings for SCZ and ASD, protein interaction data…

… of schizophrenia (1) was proposed, the first report of synaptic … the probability of developing
schizophrenia and interact with … on schizophrenia, published in 2014 and involving genomes …

… for schizophrenia research. In this review, we provide a survey of human brain cellular
composition and development, levels of genomic … schizophrenia synaptic dysfunction in the future. …

… Genome-wide association studies (GWAS) have identified multiple loci that influence the risk
of developing schizophrenia… of genome-wide-significant loci reported in the schizophrenia …