… in the pathogenesis of pulmonary fibrosis as well as the evidence of oxidative stress in
human IPF with emphasis on the pharmacological approach targeting oxidative stress. …

… Despite constant efforts, many therapeutic approaches failed until antifibrotic therapy
fundamentally altered the therapeutic approach in IPF (figure 1). Currently, two antifibrotic therapies …

… and macrophages, which limits scarring and fibrosis around wounds. These antifibrotic
properties are being explored for therapeutic benefits in fibrotic disorders such as IPF. The …

… time and causing the deposition of fibrotic tissue in the lungs. … , the effective therapeutic
approaches for pulmonary fibrosis … from acute lung inflammation to pulmonary fibrosis, and the …

… and/or a sibling with pulmonary fibrosis [52]. Familial IPF may … The pulmonary fibrosis-related
desmoplakin gene variant is … lead to the discovery of new IPF therapeutic approaches [87]. …

… Therefore, inhibition of these matrix metalloproteinases functions in IPF is a potential
therapeutic approach. In addition to the use of synthetic inhibitor, various natural compounds, gene …

… therapies that improve survival. The application of omics technologies has revolutionized
our approach to identifying previously unknown therapeutic … new therapeutic approaches, …

… pulmonary fibrosis (IPF). In addition to the approval and widespread availability of the first
IPF-specific therapies, … the possibility of personalized therapeutic approaches in the future. …

… List of the main innovative therapeutic approaches in preclinical or clinical testing for IPF
treatment. Treatments explored for PF resulting from COVID-19 are also reported. …

… The case for antifibrotic therapy in patients without IPF in the treatment of … therapy is based
on the spectrum of pulmonary fibrotic disease observed in COVID-19, ranging from fibrosis …