Antifibrotic therapy for idiopathic pulmonary fibrosis: time to treat

TM Maher, ME Strek - Respiratory research, 2019 - Springer
… Daily home spirometry: an effective tool for detecting progression in idiopathic pulmonary
fibrosis. Am J Respir Crit Care Med 194:989–97. The American Journal of Respiratory and …

Idiopathic pulmonary fibrosis: Disease mechanisms and drug development

P Spagnolo, JA Kropski, MG Jones, JS Lee… - … & therapeutics, 2021 - Elsevier
… The importance of dysregulation of alveolar epithelial cells in the initiation of pulmonary
fibrosis has been strengthened by the recent observation that an IPF-associated mutation in the …

Targeting GPCR signaling for idiopathic pulmonary fibrosis therapies

AJ Haak, MT Ducharme, AMD Espinosa… - Trends in …, 2020 - cell.com
… This review focuses on the roles of GPCR signaling in progression and resolution of
pulmonary fibrosis, and as targets for therapeutic intervention. Although not a focus of this review, …

[HTML][HTML] Current and emerging therapeutic approaches to pulmonary hypertension

M Bisserier, N Pradhan, L Hadri - Reviews in cardiovascular …, 2020 - ncbi.nlm.nih.gov
… In this review, we provide an overview of the current FDA-approved therapies in PAH and …
therapeutic approaches in the area of PAH, we also focus on the latest promising therapies

Adelmidrol: a new promising antioxidant and anti-inflammatory therapeutic tool in pulmonary fibrosis

R Fusco, M Cordaro, T Genovese, D Impellizzeri… - Antioxidants, 2020 - mdpi.com
… results propose adelmidrol as a therapeutic approach in the treatment of pulmonary fibrosis.
… adelmidrol as a therapeutic approach in the treatment of pulmonary fibrosis. We have …

Emerging cellular and molecular determinants of idiopathic pulmonary fibrosis

THG Phan, P Paliogiannis, GK Nasrallah… - Cellular and Molecular …, 2021 - Springer
… However, as these agents are not curative, new therapeutic approaches are needed [7] …
are essential for the development of effective IPF therapies. A number of processes and factors, …

Idiopathic pulmonary fibrosis: an update on pathogenesis

Q Mei, Z Liu, H Zuo, Z Yang, J Qu - Frontiers in pharmacology, 2022 - frontiersin.org
… , it still provides a significant research direction for combination therapy of pulmonary fibrosis.
… These clinical trials indicate that combination therapies for pulmonary fibrosis still need to …

Pathogenic mechanisms underlying idiopathic pulmonary fibrosis

BJ Moss, SW Ryter, IO Rosas - Annual Review of Pathology …, 2022 - annualreviews.org
… ILAs are correlated with histologic evidence of pulmonary fibrosis (4) and with demographic
and … Further progress in this area will likely inform novel therapeutic approaches in IPF. …

Idiopathic pulmonary fibrosis and lung cancer: mechanisms and molecular targets

B Ballester, J Milara, J Cortijo - International journal of molecular sciences, 2019 - mdpi.com
… However, we are some distance from realising effective therapeutic approaches that are
capable of stopping the disease process, where disease progression still occurs in most IPF …

LOX/LOXL in pulmonary fibrosis: potential therapeutic targets

L Chen, S Li, W Li - Journal of drug targeting, 2019 - Taylor & Francis
… the current clinical approaches for IPF and … pulmonary fibrosis. Although these findings
are controversial and require further validation, LOX/LOXL1/LOXL2 as potential therapeutic